The influence of mesolimbic-hippocampal interactions on episodic memory during active information seeking
主动信息寻求过程中中边缘-海马相互作用对情景记忆的影响
基本信息
- 批准号:10621702
- 负责人:
- 金额:$ 54.72万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-05-15 至 2027-02-28
- 项目状态:未结题
- 来源:
- 关键词:Active LearningAdaptive BehaviorsAnimal ModelBehaviorBehavior assessmentBehavioralBehavioral ParadigmCognitiveComputer ModelsCorpus striatum structureCuesDecision MakingDevelopmentDopamineElementsEnvironmentEpisodic memoryEventFeedbackFunctional Magnetic Resonance ImagingFutureHippocampusHumanIncubatedIndividualIndividual DifferencesKnowledgeLearningMediatingMemoryModelingMotivationOutcomePerceptionPharmaceutical PreparationsPhasePre-Clinical ModelProcessPsychiatryPsychological reinforcementRelapseResearchRewardsRiskRisk FactorsRodentSamplingShapesSignal TransductionSubstance abuse problemSupport SystemTestingUncertaintyVentral Tegmental Areaanimal datacontextual factorscravingdrug seeking behaviorexperienceforgettinginformation processinginformation seeking behaviorinsightlong term memorymemory consolidationmemory encodingmesolimbic systemmotivated behaviorneuroimagingnovelresponsesubstance usetool
项目摘要
PROJECT SUMMARY
Interactions between the hippocampus and mesolimbic dopamine system supports memory encoding and
subsequent consolidation to stabilize salient information in long-term memory. These episodic traces are used
to support a variety of adaptive behaviors, including inference, generalization, and decision-making.
Information seeking further represents a context in which motivated learning occurs in the absence of explicit
reward, including incubation-induced craving and context-dependent feedback. In this way, information seeking
may serve as a model to dissect how mesolimbic-hippocampal circuits contribute to the complexity of drug
seeking behavior. Most research characterizing the contributions of mesolimbic-hippocampal interactions on
memory have focused on reward. However, this circuit is also critically involved in memory enhancements
resulting from active exploration. Critically, memory enhancements during active information seeking involves
the integration of mesolimbic signaling across multiple elements of an event (cues versus outcomes) and
timescales (event-evoked versus state-dependent). Rodent studies show that hippocampal engagement during
exploration triggers a positive feedback loop, which increases tonic dopamine signaling in the ventral
tegmental area (VTA), which in turn yields larger VTA anticipation and feedback responses. Prominently, these
positive feedback loops could instantiate and propagate the variety of behaviors contributing to substance use.
We propose to characterize how state-dependent VTA responses relate to memory enhancements during
active information seeking using a combination of novel behavioral paradigms, state-of-the-art neuroimaging,
and computational modeling to inform mechanisms underlying memory. Aim 1 will study mesolimbic-
hippocampal contributes to memory encoding during active learning and hypothesis testing. Aim 2 will study
how engagement of this circuit during encoding stabilizes memory representations during periods of post-
encoding consolidation. Finally, Aim 3 will utilize a computational psychiatry approach to study how individual
differences in memory during active information seeking relates to predictors of substance use risk.
项目摘要
海马和中脑边缘多巴胺系统之间的相互作用支持记忆编码,
随后巩固以稳定长期记忆中的显著信息。这些情节性的痕迹
支持各种自适应行为,包括推理、泛化和决策。
信息寻求进一步代表了一种情境,在这种情境中,动机性学习发生在缺乏外显知识的情况下。
奖励,包括孵化诱导的渴望和上下文相关的反馈。这样,信息搜索
可以作为一个模型来剖析中缘-海马回路如何有助于药物的复杂性,
寻求行为。大多数研究表明中缘-海马相互作用对
记忆集中在奖励上。然而,这种电路也与记忆增强密切相关
积极探索的结果。重要的是,在主动信息搜索过程中的记忆增强包括
跨事件的多个元素(线索与结果)的中脑边缘信号的整合,
时间尺度(事件诱发与状态依赖)。啮齿类动物的研究表明,
探索触发了一个正反馈回路,这增加了腹侧多巴胺信号的紧张性。
被盖区(VTA),这反过来又产生更大的VTA预期和反馈反应。特别是,这些
正反馈循环可以实例化和传播有助于物质使用的各种行为。
我们建议描述状态依赖性VTA响应如何与记忆增强相关,
主动的信息搜索,结合了新颖的行为范例,最先进的神经成像技术,
和计算建模来告知记忆的潜在机制。目标1将研究中脑边缘-
海马在主动学习和假设检验过程中参与记忆编码。目标2将研究
编码期间该回路的参与如何在后时期稳定记忆表征
编码合并。最后,目标3将利用计算精神病学方法来研究个人如何
主动信息寻求期间的记忆差异与物质使用风险的预测因素有关。
项目成果
期刊论文数量(0)
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Vishnu Pradeep Murty其他文献
Vishnu Pradeep Murty的其他文献
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{{ truncateString('Vishnu Pradeep Murty', 18)}}的其他基金
The influence of mesolimbic-hippocampal interactions on episodic memory during active information seeking
主动信息寻求过程中中边缘-海马相互作用对情景记忆的影响
- 批准号:
10344662 - 财政年份:2022
- 资助金额:
$ 54.72万 - 项目类别:
The development of adaptive memory across early childhood
幼儿期适应性记忆的发展
- 批准号:
10527472 - 财政年份:2022
- 资助金额:
$ 54.72万 - 项目类别:
Influence of reward on memory consolidation in adults and adolescence
奖励对成人和青少年记忆巩固的影响
- 批准号:
9450704 - 财政年份:2019
- 资助金额:
$ 54.72万 - 项目类别:
Neurodevelopment of Mesolimbic Afferents in Healthy Adolescents and First-Episode Psychosis
健康青少年和首发精神病中脑边缘传入神经发育
- 批准号:
9384024 - 财政年份:2017
- 资助金额:
$ 54.72万 - 项目类别:
Neurodevelopment of Mesolimbic Afferents in Healthy Adolescents and First-Episode Psychosis
健康青少年和首发精神病中脑边缘传入神经发育
- 批准号:
10227963 - 财政年份:2017
- 资助金额:
$ 54.72万 - 项目类别:
Neurodevelopment of Mesolimbic Afferents in Healthy Adolescents and First-Episode Psychosis
健康青少年和首发精神病中脑边缘传入神经发育
- 批准号:
9542387 - 财政年份:2017
- 资助金额:
$ 54.72万 - 项目类别:
Neurodevelopment of Mesolimbic Afferents in Healthy Adolescents and First-Episode Psychosis
健康青少年和首发精神病中脑边缘传入神经发育
- 批准号:
10002289 - 财政年份:2017
- 资助金额:
$ 54.72万 - 项目类别:
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