The influence of mesolimbic-hippocampal interactions on episodic memory during active information seeking

主动信息寻求过程中中边缘-海马相互作用对情景记忆的影响

基本信息

  • 批准号:
    10621702
  • 负责人:
  • 金额:
    $ 54.72万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-05-15 至 2027-02-28
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Interactions between the hippocampus and mesolimbic dopamine system supports memory encoding and subsequent consolidation to stabilize salient information in long-term memory. These episodic traces are used to support a variety of adaptive behaviors, including inference, generalization, and decision-making. Information seeking further represents a context in which motivated learning occurs in the absence of explicit reward, including incubation-induced craving and context-dependent feedback. In this way, information seeking may serve as a model to dissect how mesolimbic-hippocampal circuits contribute to the complexity of drug seeking behavior. Most research characterizing the contributions of mesolimbic-hippocampal interactions on memory have focused on reward. However, this circuit is also critically involved in memory enhancements resulting from active exploration. Critically, memory enhancements during active information seeking involves the integration of mesolimbic signaling across multiple elements of an event (cues versus outcomes) and timescales (event-evoked versus state-dependent). Rodent studies show that hippocampal engagement during exploration triggers a positive feedback loop, which increases tonic dopamine signaling in the ventral tegmental area (VTA), which in turn yields larger VTA anticipation and feedback responses. Prominently, these positive feedback loops could instantiate and propagate the variety of behaviors contributing to substance use. We propose to characterize how state-dependent VTA responses relate to memory enhancements during active information seeking using a combination of novel behavioral paradigms, state-of-the-art neuroimaging, and computational modeling to inform mechanisms underlying memory. Aim 1 will study mesolimbic- hippocampal contributes to memory encoding during active learning and hypothesis testing. Aim 2 will study how engagement of this circuit during encoding stabilizes memory representations during periods of post- encoding consolidation. Finally, Aim 3 will utilize a computational psychiatry approach to study how individual differences in memory during active information seeking relates to predictors of substance use risk.
项目总结

项目成果

期刊论文数量(0)
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Vishnu Pradeep Murty其他文献

Vishnu Pradeep Murty的其他文献

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{{ truncateString('Vishnu Pradeep Murty', 18)}}的其他基金

The influence of mesolimbic-hippocampal interactions on episodic memory during active information seeking
主动信息寻求过程中中边缘-海马相互作用对情景记忆的影响
  • 批准号:
    10344662
  • 财政年份:
    2022
  • 资助金额:
    $ 54.72万
  • 项目类别:
The development of adaptive memory across early childhood
幼儿期适应性记忆的发展
  • 批准号:
    10527472
  • 财政年份:
    2022
  • 资助金额:
    $ 54.72万
  • 项目类别:
Influence of reward on memory consolidation in adults and adolescence
奖励对成人和青少年记忆巩固的影响
  • 批准号:
    9450704
  • 财政年份:
    2019
  • 资助金额:
    $ 54.72万
  • 项目类别:
Neurodevelopment of Mesolimbic Afferents in Healthy Adolescents and First-Episode Psychosis
健康青少年和首发精神病中脑边缘传入神经发育
  • 批准号:
    9384024
  • 财政年份:
    2017
  • 资助金额:
    $ 54.72万
  • 项目类别:
Neurodevelopment of Mesolimbic Afferents in Healthy Adolescents and First-Episode Psychosis
健康青少年和首发精神病中脑边缘传入神经发育
  • 批准号:
    10227963
  • 财政年份:
    2017
  • 资助金额:
    $ 54.72万
  • 项目类别:
Neurodevelopment of Mesolimbic Afferents in Healthy Adolescents and First-Episode Psychosis
健康青少年和首发精神病中脑边缘传入神经发育
  • 批准号:
    9542387
  • 财政年份:
    2017
  • 资助金额:
    $ 54.72万
  • 项目类别:
Neurodevelopment of Mesolimbic Afferents in Healthy Adolescents and First-Episode Psychosis
健康青少年和首发精神病中脑边缘传入神经发育
  • 批准号:
    10002289
  • 财政年份:
    2017
  • 资助金额:
    $ 54.72万
  • 项目类别:
Single-trial reward learning and generalization
单次试验奖励学习和泛化
  • 批准号:
    8962069
  • 财政年份:
    2014
  • 资助金额:
    $ 54.72万
  • 项目类别:
Single-trial reward learning and generalization
单次试验奖励学习和泛化
  • 批准号:
    8718412
  • 财政年份:
    2014
  • 资助金额:
    $ 54.72万
  • 项目类别:

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