Generation of a Public Resource of Mouse Strain Sequences

小鼠品系序列公共资源的生成

• 批准号: G0800024/1
• 负责人: Allan Bradley
• 金额: $ 293.07万
• 依托单位: Wellcome Sanger Institute
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0800024%2F1
• 关键词: Generation; Public; Resource; Mouse; Strain

In this project we will decode the genomes of 17 key mouse strains that are used extensively as models of human disease by using DNA sequencing. By having the DNA sequence of these mouse strains we will be able to better understand what makes each mouse strain unique and this will in turn illuminate the basis behind genetic variation and disease susceptibility in humans.

在这个项目中，我们将通过DNA测序来解码被广泛用作人类疾病模型的17个关键小鼠品系的基因组。通过获得这些小鼠品系的DNA序列，我们将能够更好地了解是什么使每个小鼠品系独一无二，这将反过来阐明人类遗传变异和疾病易感性背后的基础。