Molecular dissection of c-Myc function in self renewal/differentiation of neural stem cells

c-Myc在神经干细胞自我更新/分化中功能的分子解析

• 批准号: G0800020/1
• 负责人: Silvia Marino
• 金额: $ 50.22万
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0800020%2F1
• 关键词: Molecular; dissection; Myc; function; self

Recent discoveries in cell biology have shown that genes previously implicated in a variety of forms of cancer are also key regulators of the proliferation of normal stem cells. Various signals instruct cells whether to grow or to stop and become a particular cell type. These signals are crucial for proper organ function because the formation of a specific organ depends on the right amount of cell growth being balanced with the right ratio of cells forming differentiated and specialised cells. Here we will focus on brain stem cells and we will perform experiments to examine the function of particular genes, c-Myc and Bmi1, in regulating basic stem cell properties, such as proliferation/self renewal and differentiation. We hope these studies will provide insight into how neural stem cells are regulated during brain development and in neurogenic area of the adult brain.Understanding how specific genes promote the proliferation of neural stem cells will allow us to set the basis for a potential future development of new treatments for currently incurable brain diseases and injuries.

细胞生物学的最新发现表明，先前与多种癌症有关的基因也是正常干细胞增殖的关键调节因子。各种信号指示细胞是生长还是停止并变成特定的细胞类型。这些信号对于正常的器官功能至关重要，因为特定器官的形成取决于适量的细胞生长与形成分化和特化细胞的正确比例的平衡。在这里，我们将重点关注脑干细胞，我们将进行实验来检查特定基因 c-Myc 和 Bmi1 在调节基本干细胞特性（例如增殖/自我更新和分化）方面的功能。我们希望这些研究能够深入了解神经干细胞在大脑发育过程中以及成人大脑神经源性区域中如何受到调节。了解特定基因如何促进神经干细胞增殖将使我们能够为未来开发针对目前无法治愈的脑部疾病和损伤的新疗法奠定基础。