Biochemical and molecular dissection of the mechanisms controlling ribosome biogenesis by the PI3K/AKT/mTOR/MYC network

通过 PI3K/AKT/mTOR/MYC 网络控制核糖体生物发生机制的生化和分子解剖

• 批准号: nhmrc : 1004881
• 负责人: Prof Richard Pearson
• 金额: $ 36.35万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/biochemical-molecular-dissection-pi3kaktmtormyc-network/109076
• 关键词: Biochemical; molecular; dissection; mechanisms; controlling

Ribosome synthesis and function are critical for normal cell growth and division and hence this process is exquisitely regulated. Conversely, de-regulated cell growth can lead to cancer. We have identified new roles for the AKT and SGK families of kinases in controlling this process. This proposal aims to establish the mechanisms by which these enzymes control ribosome synthesis to better understand growth control and to provide insight for targeting these pathways in growth driven cancers.

核糖体合成和功能对于正常细胞生长和分裂至关重要，因此该过程受到严格调控。相反，细胞生长失调会导致癌症。我们已经确定了 AKT 和 SGK 激酶家族在控制这一过程中的新作用。该提案旨在建立这些酶控制核糖体合成的机制，以更好地了解生长控制，并为在生长驱动的癌症中靶向这些途径提供见解。