Impact of peripheral inflammation on cerebrovascular disease

周围炎症对脑血管疾病的影响

• 批准号: G0802001/1
• 负责人: Nancy Rothwell
• 金额: $ 101.05万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0802001%2F1
• 关键词: Impact; peripheral; inflammation; cerebrovascular; disease

The blood supply to the brain provides essential oxygen and nutrients to support brain function. During stroke the blood supply to the brain may be reduced or blocked. This causes nerve cells in the brain to die, which can be fatal for the patient or leave them severely disabled. Although some treatments are available for stroke, these are not suitable for all patients and not always widely effective. We need therefore to understand more about why stroke occurs and what causes the brain cells to die so that new treatments can be developed.Inflammation is the response of the body to fight infection, but it can also lead to a variety of diseases, such as arthritis and asthma. The inflammation that occurs outside the brain, for example in a blood vessel, can contribute to the development of conditions such as stroke and make the patient much worse. Therefore in this proposal our aim is to understand how inflammation and infection outside the brain affect events within the brain. To do this we will study animals that develop disease of their blood vessels in much the same way that many humans do, to see if this causes strokes and, if so, how. The studies should help us to identify better animal models of human stroke in which to test new treatments. We also aim to discover substances within the blood or brain that can predict the occurrence of brain diseases such as stroke, so that patients can be treated early.

大脑的血液供应提供必要的氧气和营养物质来支持大脑功能。在中风期间，大脑的血液供应可能会减少或阻塞。这会导致大脑中的神经细胞死亡，这对患者来说可能是致命的，或者使他们严重残疾。虽然有一些治疗中风的方法，但这些方法并不适合所有患者，也不总是广泛有效。因此，我们需要更多地了解中风发生的原因以及导致脑细胞死亡的原因，以便开发新的治疗方法。炎症是身体对抗感染的反应，但它也可能导致多种疾病，如关节炎和哮喘。发生在脑外的炎症，例如血管中的炎症，可能会导致中风等疾病的发展，并使患者病情恶化。因此，在这项提案中，我们的目标是了解大脑外部的炎症和感染如何影响大脑内部的事件。为了做到这一点，我们将研究与许多人一样发展血管疾病的动物，看看这是否会导致中风，如果是这样，如何。这些研究应该有助于我们确定更好的人类中风动物模型，以测试新的治疗方法。我们还旨在发现血液或大脑中可以预测中风等脑部疾病发生的物质，以便及早治疗患者。