Short-term and long-term impact of COVID-19 on multiple sensory systems

COVID-19 对多种感觉系统的短期和长期影响

• 批准号: 10564687
• 负责人: KAI ZHAO
• 金额: $ 51.94万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-02-01 至 2028-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10564687
• 关键词: 2019-nCoV; ACE2; Acute; Affect; Ageusia; Anosmia; Auditory; Basal Cell; COVID-19; COVID-19 impact; COVID-19 long hauler; COVID-19 pandemic; COVID-19 patient; COVID-19 screening; Case Study; Cessation of life; Characteristics; China; Cochlea; Common Cold; Confusion; Coronavirus; Coughing; Data; Dendrites; Disease; Disease Outbreaks; Dizziness; Epidemiologist; Equilibrium; Face; Fever; Functional disorder; Future; General Population; Glucose; Goals; Handwashing; Headache; Hearing; Herpes Simplex Infections; Hospitalization; Hypoxia; Impairment; Individual; Infection; Inflammation; Ion Exchange; Labyrinth; Long COVID; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Methodology; Modality; Mucous body substance; Neurologic; Neurologic Symptoms; Olfactory Epithelium; Outcome Study; Pathway interactions; Patient Care; Patient Self-Report; Patients; Perception; Peripheral; Persons; Phase; Public Health; Recovery; Reporting; Research; SARS-CoV-2 B.1.1.529; SARS-CoV-2 B.1.617.2; SARS-CoV-2 infection; Schools; Sensory; Severities; Severity of illness; Smell Perception; Social Distance; Sudden Hearing Loss; Supporting Cell; Symptoms; System; Taste Perception; Testing; Time; Tinnitus; Trigeminal System; Upper Respiratory Infections; Vaccination; Variant; Vertigo; Viral; Virus; Virus Diseases; West Nile; Workplace; ZIKA; cohort; common symptom; comparison group; coronavirus disease; dashboard; epidemiology study; expectation; flu; health care settings; long term consequences of COVID-19; multidisciplinary; multisensory; nasal obstruction; neural; neuroinflammation; neurosensory; neurotropic; olfactory bulb; olfactory sensory neurons; pandemic disease; patient subsets; persistent symptom; post-COVID-19; receptor; sensory system; sustentacular cell; timeline; variants of concern

Project Summary Since its outbreak in China in December 2019, the global impact of SARS-CoV-2 infection has been extraordinary, with over 350 million cases and more than 5.5 million lives lost (WHO Coronavirus Dashboard, Jan 2022). Despite various public health measures, such as social distancing, handwashing, face masking, and vaccination, infections in the US and the world continue in waves driven by new variants of concern (WHO). While the pandemic landscape has been constantly shifting, epidemiologists and public health experts increasingly project that the virus could eventually become endemic, especially with emerging zoological reservoirs. While information is still emerging, the full picture of neurological consequences of COVID-19 to broad sensory functions remains unclear, especially in the context of new variants, vaccination, prior infection, and ongoing treatment. For example, smell loss has been a hallmark symptom of COVID-19 (>80%) and can present in isolation (the only symptom of COVID-19) or precede the occurrence of other symptoms. Epidemiology studies have shown that smell loss is the most predictive symptom for COVID-19, better in identifying COVID-19 patients than cough, fever, headache, or other typical symptoms used to screen for COVID-19 in workplaces, schools, and health care settings. But with the emergence of Delta and Omicron variants and vaccination, it is unclear whether olfaction function is still severely impacted as in the early stage of the pandemic. Similarly, taste and chemesthesis (trigeminal) losses have been implicated but not fully differentiated from the flavor loss caused by retronasal smell losses. Sudden onset of hearing loss and dizziness have also been self-reported among COVID-19 patients, but current evidence for these are still limited, despite being in the 3rd year of the pandemic. In this study, Aim 1 will apply multidisciplinary methodologies to extensively capture and quantify the full impact of COVID-19 on broad sensory functions (smell, taste, chemesthesis, hearing, balance/vestibular function), with endemic viral upper respiratory infection (URI: cold, flu, etc.) as a comparison group. These tests will allow us to extensively explore and differentiate the impact of COVID-19 on multiple sensory functions and their association with the disease profile, such as severity, dominant variant at the time of infection, vaccination status, prior infections, and treatment received, with potential to characterize common and distinct factors to that of URI. Aim 2 will broadly assess the longitudinal time course of sensory loss and recovery among COVID-19 patients, with the expectation that recovery can vary depending on the system affected and the disease profile. Aim 3 will specifically focus on COVID-19 “long haulers”, patients who have persistent symptoms (>90 days), to examine the different characteristics in sensory losses and recovery during the prolonged disease phase. The outcomes of this study could importantly expand our understanding of the characteristics of broad sensory losses and their recovery among COVID-19 patients.

项目摘要 自2019年12月在中国爆发以来，SARS-COV-2感染的全球影响 非常非凡，案件超过3.5亿，丧生超过550万（谁） 冠状病毒仪表板，2022年1月）。尽管采取了各种公共卫生措施，例如社会 距离，洗手，面罩和疫苗接种，美国和世界的感染 继续以新的关注变体（WHO）驱动的波浪。而大流行景观 流行病学家和公共卫生专家一直在不断变化 该病毒最终可能成为内在，尤其是随着新兴的动物储量。 虽然信息仍在出现，但COVID-19的神经系统后果的全部图是 广泛的感官功能尚不清楚，尤其是在新变体的背景下，疫苗接种， 事先感染和持续治疗。例如，气味流失一直是 COVID-19（> 80％），可以孤立地存在（唯一的covid-19符号）或之前 流行病学研究表明，气味丧失是最大的 Covid-19的预测症状，比Coug比Coug，发烧，更好地识别Covid-19患者更好 头痛或其他典型症状用于筛查工作场所，学校和 医疗保健环境。但是，随着三角洲和Omicron变体和疫苗接种的出现，它是 尚不清楚嗅觉功能是否仍然像在 大流行。同样，味道和化学术（三叉神经）损失也被暗示，但不是 与腹侧气味损失引起的风味丧失完全不同。突然发作 在199例患者中，听力损失和头晕也已经自我报告，但目前 这些证据仍然是有限的，在大流行的第三年，dospite是有限的。在这项研究中， AIM 1将采用多学科方法来广泛捕获和量化 COVID-19对广泛感觉功能的影响（气味，味觉，化学，听力，听力， 平衡/前庭功能），带有特有病毒上呼吸道感染（URI：冷，流感等） 作为比较组。这些测试将使我们能够广泛探索和区分 COVID-19对多种感觉函数的影响及其与疾病特征的关联， 例如严重程度，感染时的主要变异，疫苗接种状况，先前感染， 和接受的治疗，具有表征共同和不同因素的潜力 Uri。 AIM 2将广泛评估感觉丧失和恢复的纵向时间课程 COVID-19患者，期望恢复会因系统而有所不同 AIM 3将特别关注COVID-19-19 有持续症状的患者（> 90天），以检查不同特征 长期疾病阶段的感觉损失和恢复。这项研究的结果 重要的是，我们可以扩大我们对广泛感官损失特征的理解和 他们在199名患者中恢复。