Exploiting Non-Linear Acoustics for Enhanced Molecular Delivery

利用非线性声学增强分子传递

• 批准号: G0802645/1
• 负责人: Paul Campbell
• 金额: $ 11.07万
• 依托单位: University of Dundee
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0802645%2F1
• 关键词: Exploiting; Non; Linear; Acoustics; Enhanced

RNAi is a new form of therapy that allows faulty genes to be switched off in a wide range of genetic diseases and in cancer. The barrier to applying this revolutionary new form of medicine is how to deliver it into the body, since the molecules involved are larger than normal drugs and so cells require some help in taking this material up so it can have its beneficial effect. The main aim of this project is to revolutionise the delivery of these new therapeutics into the skin, as a test organ system by exploiting the penetrating effect of ultrasound activated microbubbles. Skin has the advantage of being on the outside of the body for easy access, and excess human skin from cosmetic surgery (breast reductions and tummy tucks) is readily available for experimentation to optimise delivery of RNAi molecules. In pursuit of this, we will develop an innovative new tool combining chemistry, ultrasound and arrays of microscopic painless needles for fast, effective and reliable delivery into skin at high coverage rates. Once optimised for skin diseases, this hand-held device will be readily adapted for use on internal organs using keyhole surgery methods, so that the potential applications of this device across all branches of medicine are huge. The team assembled in Dundee brings together a leading molecular biologist with a physicist, but supported by further international collaborators with diverse skills across many different fields, in order to piece together elements of technology in ways that have never been done before. The estimated market for solving the therapy delivery problem being tackled here is in the order of 10s of billions of dollars per year.Ultrasound, as prescribed in the manner presented, looks like a very promising route to achieving that goal.

RNAi是一种新的治疗形式，它可以在广泛的遗传疾病和癌症中关闭缺陷基因。应用这种革命性的新形式药物的障碍是如何将其输送到体内，因为所涉及的分子比正常药物大，因此细胞需要一些帮助才能吸收这种材料，这样它才能产生有益的效果。该项目的主要目的是通过利用超声激活微泡的穿透作用，彻底改变这些新疗法在皮肤中的递送，作为测试器官系统。皮肤具有位于身体外部以便于接近的优点，并且来自整容手术（乳房缩小和腹部整形）的多余人类皮肤易于用于实验以优化RNAi分子的递送。为了实现这一目标，我们将开发一种创新的新工具，将化学、超声波和显微无痛针阵列相结合，以高覆盖率快速、有效和可靠地输送到皮肤中。一旦针对皮肤疾病进行了优化，这种手持式设备将很容易适用于使用锁孔手术方法的内部器官，因此该设备在所有医学分支中的潜在应用是巨大的。该团队聚集在邓迪，汇集了一位领先的分子生物学家和一位物理学家，但得到了更多国际合作者的支持，他们在许多不同领域拥有不同的技能，以便以前所未有的方式将技术元素拼凑在一起。用于解决这里所处理的治疗递送问题的估计市场每年大约为100亿美元。超声，如以所提出的方式所规定的，看起来是实现该目标的非常有前途的途径。