MAGNETIC RESONANCE IMAGINGIN ASEPTIC NECROSIS OF THE FEMORAL HEADS

股骨头无菌性坏死的磁共振成像

• 批准号: 3963145
• 负责人: B PASTAKIA
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3963145
• 关键词: computed axial tomography; human subject; musculoskeletal disorder diagnosis; musculoskeletal imaging /visualization /scanning; necrosis; nuclear medicine; radionuclide imaging /scanning; sickle cell anemia; systemic lupus erythematosus

Patients with suspected aseptic necrosis (AN) of the femoral heads (carrying a diagnosis of Sickle Cell Anemia or Systemic Lupus Erythematosus) with normal plain x-rays of their hips undergo MRI and multiplanar reformation (MPR) on the CT scanner to determine whether any of the newly developed techniques in radiology is more sensitive than radionuclide imaging in making the diagnosis of AN. All studies, including those in nuclear medicine, are performed within one week of each other. Since entry criteria into this protocol are strict, only 10 patients have been admitted to it and the number of patients is too small at present to make an assessment regarding the efficacy of one technique over the other. The study also will provide a means to understand the natural history of the disease process, as we plan to repeat the radiographic studies at six months and one year after the initial examinations.

疑似股骨头无菌性坏死（AN）的患者 （如诊断为镰状细胞贫血或系统性狼疮 红斑）与正常的平片X线检查，他们的臀部进行MRI， 在CT扫描仪上进行多平面重组（MPR），以确定 放射学中新开发的技术比 放射性核素显像对AN的诊断价值。 所有研究，包括 在核医学中，它们彼此在一周内进行。 由于该方案的入选标准很严格，只有10名患者 目前，患者人数太少， 评估一种技术相对于另一种技术的功效。 这项研究还将提供一种手段，以了解自然历史， 疾病的过程，因为我们计划在六岁时重复放射学研究， 在初次检查后的一个月和一年内。