RADIOGRAPHIC MANIFESTATIONS OF THE NEVOID BASAL CELL CARCINOMA SYNDROME

共有5个家族的100名患者患有新生血管。 细胞癌(NBCC)综合征将被研究用于遗传分析， 细胞表型/细胞遗传学及其与分子的合作研究 生物学家试图从NBCC细胞中分离出一种可转化的基因 异常表型由正常表型转为异常表型。在本研究的部分 指定的“证候勾画”诊断放射学起着重要作用 角色。 大量骨骼异常、内脏损害(由腹部和 骨盆超声)和脑内发育不良病变(CT研究 扫描)被记录下来。到目前为止(1985年5月)，大约有25名患者被 承认了这一协议。以前未被识别的骨骼变化 到目前为止，在研究的患者中发现了NBCC。我们还有 在这一组中，记录的胆结石发病率高于正常水平 与普通人群相比，患者的比例更高。较大数字的应计项目 案件的数量正在等待作出明确的陈述。

A total of 100 patients belonging to five families with the Nevoid Basal Cell Carcinoma (NBCC) Syndrome are to be studied for genetic analysis, cellular phenotype/cytogenetics and collaborative studies with molecular biologists in an attempt to isolate a geneable to transform NBCC cells from an abnormal phenotype to a normal phenotype. In the portion of this study designated "syndrome delineation" diagnostic radiology plays a significant role. Numerous skeletal abnormalities, visceral lesions (studied by abdominal and pelvic ultrasound) and dysplastic lesions in the brain (studied by CT scans) are noted. So far (May 1985) about twenty-five patients have been admitted to this protocol. Previously unrecognized skeletal changes in NBCC have been found in the patients studied to date. We have also documented a higher than usual incidence of gallstones in this group of patients as compared to the general population. Accrual of larger numbers of cases is awaited to make definitive statements.