The role of MRAPs in the control of melanocortin receptor dependent energy homeostasis and adrenal function

MRAP 在控制黑皮质素受体依赖性能量稳态和肾上腺功能中的作用

• 批准号: G0802796/1
• 负责人: Li Chan
• 金额: $ 130.65万
• 依托单位: Queen Mary University of London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0802796%2F1
• 关键词: role; MRAPs; control; melanocortin; receptor

The ‘melanocortin receptors‘ are an important group of proteins which are found on the surface of cells at many places in the body. They are responsible for a large number of different processes such as food metabolism, feeding behaviour and stress responses. Diseases which can present in childhood, such as severe obesity and the inability to fight infections, arise when these receptors fail to work properly. In the laboratory we have now identified two other proteins called MRAPs (Melanocortin Receptor Accessory Proteins) that affect the way in which the melanocortin receptors work. By studying the MRAP proteins in cells, and what happens when the MRAP proteins are absent, we will better understand how the MRAP/Melanocortin receptors work together, and how defects in them could lead to disease. In the long-term this understanding may help in the development of new drugs for the treatment of conditions such as obesity.

“黑皮质素受体”是一组重要的蛋白质，在体内许多地方的细胞表面上发现。它们负责许多不同的过程，如食物代谢、摄食行为和应激反应。当这些受体不能正常工作时，儿童时期可能出现的疾病，如严重肥胖和无法抵抗感染。在实验室中，我们现在已经确定了另外两种称为MRAP（黑皮质素受体辅助蛋白）的蛋白质，它们影响黑皮质素受体的工作方式。通过研究细胞中的MRAP蛋白，以及当MRAP蛋白缺失时会发生什么，我们将更好地了解MRAP/黑皮质素受体如何共同工作，以及它们的缺陷如何导致疾病。从长远来看，这种理解可能有助于开发治疗肥胖等疾病的新药。