Enhancing the Efficacy of TCR Gene Therapy by Co-Transfer of CD3 Molecules

通过 CD3 分子共转移增强 TCR 基因治疗的功效

• 批准号: G0900397/1
• 负责人: Emma Nicholson
• 金额: $ 33.78万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0900397%2F1
• 关键词: Enhancing; Efficacy; TCR; Gene; Therapy

Although the immune system can protect people against virus infection, its ability to protect against the growth of leukaemia cells is impaired. One reason for this impairment is that the immunesystem often fails to recognise leukaemia cells. In this project, we will insert genes into immune cells in order to improve their ability to recognise leukaemia cells. We will optimise the gene transferstrategy and test in an experimental model whether the gene modified immune cells can protect against the growth of leukaemia cells.

虽然免疫系统可以保护人们免受病毒感染，但其防止白血病细胞生长的能力受到损害。这种损害的一个原因是免疫系统通常无法识别白血病细胞。在这个项目中，我们将基因插入免疫细胞，以提高它们识别白血病细胞的能力。我们将优化基因转移策略，并在实验模型中测试基因修饰的免疫细胞是否可以防止白血病细胞的生长。