ASSESSMENT OF THE SIZE OF THE LEAK INDUCED IN RETINAL VESSELS USING PITC-DEXTRANS

使用 PITC-DEXTRANS 评估视网膜血管渗漏的大小

• 批准号: 3965400
• 负责人: S LIGHTMAN
• 金额: --
• 依托单位: NATIONAL EYE INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3965400
• 关键词: angiography; dextrans; disease /disorder model; eye disorder diagnosis; fluorescent dye /probe; retina circulation disorder; uveitis

Uveitis was induced in two monkeys by immunization with IRBP and serial fluorescein angiograms preformed using different sized dextrans linked to fluorescein. The aim of these studies is to provide data on the retinal vessels and toxicology data to enable these agents to be used in humans. We have demonstrated that the larger molecular weight dextrans are less premeable than sodium fluorescein in the inflamed retina.

用IRBP免疫两只猴子， 荧光素血管造影使用不同大小的葡聚糖连接到 荧光素 这些研究的目的是提供视网膜病变的数据， 血管和毒理学数据，使这些试剂用于人类。 我们已经证明，分子量较大的右旋糖酐较少 比荧光素钠更有效