LEFT VENTRICULAR FUNCTION AFTER VALVE REPLACEMENT FOR AORTIC REGURGITATION

主动脉瓣关闭不全瓣膜置换术后的左心室功能

• 批准号: 3966728
• 负责人: R O BONOW
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3966728
• 关键词: angiography; aortic valve insufficiency; echocardiography; heart dimension /size; heart disorder diagnosis; heart function; heart surgery; heart valve transplantation; human subject; postoperative state; radionuclide diagnosis

In the majority of patients with aortic regurgitation, valve replacement results in reduction in left ventricular dilatation and improvement in ejection fraction. To determine the relation between serial changes in left ventricular diastolic dimension and simultaneous changes in ejection fraction, we studied 50 patients by both echocardiography and radionuclide angiography before operation and early (6-8 months) and late (3-7 years) after operation. During both early and late postoperative evaluations, changes in diastolic size correlated significantly with changes in ejection fraction (p less than .001). Late improvement in ejection fraction after the early study occurred only in those patients manifesting an increase in ejection fraction between the preoperative and early postoperative studies. These improvements occurred predominantly in patients with normal preoperative ejection fraction or patients with subnormal ejection fraction but with preserved exercise tolerance and only a brief duration (p less than 14 months) of preoperative left ventricular dysfunction.

在大多数主动脉瓣返流患者中， 导致左心室扩张减少， 射血分数 为了确定连续变化之间的关系 左室舒张期内径与射血功能的同步变化 部分，我们研究了50例患者的超声心动图和放射性核素 术前、早期（6-8个月）和晚期（3-7年）血管造影 术后 在术后早期和晚期评估期间， 舒张期大小的变化与射血功能的变化显著相关 分数（p小于.001）。 射血分数晚期改善， 早期的研究只发生在那些表现出增加的患者中， 术前和术后早期之间的射血分数 问题研究 这些改善主要发生在具有正常 术前射血分数或射血分数低于正常的患者 但运动耐量保持不变且持续时间较短（P <0.05）， 14个月以上）术前左心室功能不全。