LEFT VENTRICULAR EJECTION DYNAMICS IN HYPERTROPHIC CARDIOMYOPATHY

肥厚型心肌病的左心室射血动力学

• 批准号: 4694683
• 负责人: R O BONOW
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4694683
• 关键词: aortic valve stenosis; cardiac output; heart circulation; heart disorder diagnosis; heart imaging /visualization /scanning; human subject; hypertrophic myocardiopathy

We investigated the dynamics and timing of left ventricular ejection in patients with hypertrophic cardiomyopathy (HCM), compared to patients with valvular aortic stenosis (AS), using radionuclide angiography. Patients with obstructive HCM had prolongation of left ventricular ejection time that was equivalent to patients with AS but significantly greater than patients with HCM without gradients. Despite prolonged ejection times, obstructive HCM patients had a period of brief, rapid ejection, with time to peak ejection rate values less than normal and equivalent to patients without gradients. Of note, 40% of patients with AS had supranormal ejection fractions. Hence, 1) supranormal EF does not exclude the possibility of significant outflow obstruction in HCM or AS, and 2) the outflow gradient in HCM represents true impedance to left ventricular emptying which occurs after an initial period of rapid ejection.

我们研究了左心室射血的动力学和时间 与肥厚型心肌病 (HCM) 患者相比 主动脉瓣狭窄（AS），使用放射性核素血管造影。 患者 梗阻性 HCM 患者左心室射血时间延长 与 AS 患者相当，但显着高于 没有梯度的 HCM 患者。 尽管弹射时间较长， 梗阻性 HCM 患者有一段短暂、快速的射血期，随着时间的推移 峰值射血率值低于正常值且与患者相当 没有渐变。 值得注意的是，40% 的 AS 患者有超常症状 射血分数。 因此，1) 超常 EF 并不排除 HCM 或 AS 中存在严重流出道阻塞的可能性，以及 2) HCM 中的流出梯度代表左心室的真实阻抗 在最初的快速喷射期后发生的排空。