iPS cells from ALS patients- towards replacing animal models for ALS

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ALS is a form of neurodegenerative disorder in which Motor Neurons, the nerves that connect to the muscle die leading loss of movement and affect key body processes such as breathing, eventually causing death. Mouse models for ALS have been generated to test therapeutic interventions but many of these are not robust systems. We propose to make stem cell like cells from skin cells of ALS patients from which we can make Motor neurons. These motor neurons will provide a model more akin to the human disease and therefore serve a good model to understand the disease process as well as to test drugs.