MRC Collaborative Training Programme in Radiochemistry for NeuroPET

正电子发射断层扫描或正电子发射断层扫描允许使用极低水平的、相对安全的放射性标记示踪剂的灵敏探测器，非侵入性地绘制特定分子的数量和位置。在理想的情况下，这种方法可以在症状出现之前很久就为阿尔茨海默病等重大疾病的诊断提供关键诊断信息。这些方法还可以用来帮助更好地确保在临床试验中使用正确剂量的实验药物，从而增加成功完成试验的可能性。然而，尽管英国拥有在几家主要学术医院进行高水平放射性活动的设备，但没有足够受过专门培训的化学家来开发和生产放射性示踪剂。这项提议将创建一个新颖的4年培训计划-实际上是世界上第一个-装备两名化学家的技能和经验，成为这一领域的英国领导者。此外，这笔赠款将把以前没有合作过的中心聚集在一起，使它们能够开始为共同利益汇集资源。

Positron emission tomography or PET allows the amount and position of specific molecules to be mapped non-invasively using sensitive detectors of very low level, relatively safe radioactively tagged tracers. In the ideal case, the method could provide critical diagnostic information for the diagnosis of major diseases such as Alzheimer s disease long before symptoms may appear. The methods also can be used to help better ensure that the right dose of experimental drugs are used in clinical trials, increasing the likelihood of successful completion of the trials. However, while the UK has equipment that could allow a high level of this activity at several major academic hospitals, there are not enough chemists specially trained to develop and produce the radiotracers. This proposal would create a novel 4 year training programme- really a world first - to equip two chemists with the skills and experience to become UK leaders in this area. In addition, the grant will bring together centres that previously have not worked together, allowing them to begin to pool resources for common good.