MRC Collaborative Training Programme in Radiochemistry for NeuroPET

MRC NeuroPET 放射化学合作培训项目

• 批准号: G0900897/1
• 负责人: Paul Matthews
• 金额: $ 76.45万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0900897%2F1
• 关键词: MRC; Collaborative; Training; Programme; Radiochemistry

Positron emission tomography or PET allows the amount and position of specific molecules to be mapped non-invasively using sensitive detectors of very low level, relatively safe radioactively tagged tracers. In the ideal case, the method could provide critical diagnostic information for the diagnosis of major diseases such as Alzheimer s disease long before symptoms may appear. The methods also can be used to help better ensure that the right dose of experimental drugs are used in clinical trials, increasing the likelihood of successful completion of the trials. However, while the UK has equipment that could allow a high level of this activity at several major academic hospitals, there are not enough chemists specially trained to develop and produce the radiotracers. This proposal would create a novel 4 year training programme- really a world first - to equip two chemists with the skills and experience to become UK leaders in this area. In addition, the grant will bring together centres that previously have not worked together, allowing them to begin to pool resources for common good.

正电子发射断层扫描或PET允许使用非常低水平、相对安全的放射性标记示踪剂的敏感探测器非侵入性地绘制特定分子的数量和位置。在理想的情况下，该方法可以在症状出现之前很久就为阿尔茨海默病等重大疾病的诊断提供关键的诊断信息。这些方法还可以用来帮助更好地确保在临床试验中使用正确剂量的实验药物，增加成功完成试验的可能性。然而，虽然英国拥有可以在几家主要学术医院进行高水平活动的设备，但没有足够的经过专门培训的化学家来开发和生产放射性示踪剂。该提案将创建一个新的4年培训计划-真正的世界第一-装备两个化学家的技能和经验，成为英国在这一领域的领导者。此外，赠款将把以前没有合作过的中心聚集在一起，使它们能够开始为共同利益汇集资源。