UKDP: Integrated DEmentiA research environment (IDEA)

UKDP：综合痴呆症研究环境 (IDEA)

• 批准号: MR/M024903/1
• 负责人: Paul Matthews
• 金额: $ 709.67万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FM024903%2F1
• 关键词: UKDP; Integrated; DEmentiA; research; environment

The UK Dementias Platform (UKDP) is a radically new approach to dementias research. It brings together data fromaround 2,000,000 study participants from 22 cohorts to try and discover the causes of dementia and to find out ways ofslowing it down. The platform has been funded to the level of £12M.In this proposal we want to improve UK infrastructure for dementia research so that the most can be made of theopportunity provided by UKDP. We wan to improve the infrastructure by buying important pieces of equipment that will putthe UK at the forefront of dementia research worldwide and by establishing networks of scientists who will work together tomake best use of the equipment.The three themes of the proposal are imaging, informatics and stem cells.For imaging we want to establish a network of PET/MR scanning facilities across the UK so that the molecular processesgoing on inside the brain that cause dementia can be studied.For informatics we want to be bring together bas many different types of data as possible and make it easy as possible forscientists to use themFor stem cells we want to take cells form adults with and without dementia to find out how cells change as the dementiasprocess begins and progresses.We believe these proposals will raise standards, reduce costs, and deliver innovative and coordinated research, makingthe UK an internationally unique place to study dementia.

英国痴呆症平台(UKDP)是痴呆症研究的一种全新方法。它汇集了来自22个队列的200万名研究参与者的数据，试图发现痴呆症的原因，并找到减缓痴呆症的方法。该平台的资金水平已达到GB 12M。在这项提议中，我们希望改善英国痴呆症研究的基础设施，以便最大限度地利用英国独立党提供的机会。我们希望通过购买重要的设备来改善基础设施，这些设备将使英国处于全球痴呆症研究的前沿，并建立科学家网络，他们将共同努力，充分利用这些设备。该提案的三个主题是成像，信息学和干细胞。在成像方面，我们希望在英国各地建立一个PET/MR扫描设备网络，以便研究导致痴呆症的大脑内部的分子过程。在信息学方面，我们希望尽可能多地收集不同类型的数据，使科学家能够尽可能容易地将它们用于干细胞。我们希望从患有痴呆症和非痴呆症的成年人身上提取细胞，以了解随着痴呆症过程的开始和进展，细胞是如何变化的。我们相信，这些建议将提高标准，降低成本，并提供创新和协调的研究，使英国成为国际上唯一研究痴呆症的地方。

项目成果

Alcohol consumption in the general population is associated with structural changes in multiple organ systems.

• DOI: 10.7554/elife.65325
• 发表时间: 2021-06-01
• 期刊: eLife
• 影响因子: 7.7
• 作者: Evangelou E;Suzuki H;Bai W;Pazoki R;Gao H;Matthews PM;Elliott P
• 通讯作者: Elliott P

Improving data availability for brain image biobanking in healthy subjects: Practice-based suggestions from an international multidisciplinary working group.

• DOI: 10.1016/j.neuroimage.2017.02.030
• 发表时间: 2017-06
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: BRAINS (Brain Imaging in Normal Subjects) Expert Working Group;Shenkin SD;Pernet C;Nichols TE;Poline JB;Matthews PM;van der Lugt A;Mackay C;Lanyon L;Mazoyer B;Boardman JP;Thompson PM;Fox N;Marcus DS;Sheikh A;Cox SR;Anblagan D;Job DE;Dickie DA;Rodriguez D;Wardlaw JM
• 通讯作者: Wardlaw JM

Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank.

• DOI: 10.1016/j.neuroimage.2017.10.034
• 发表时间: 2018-02-01
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Alfaro-Almagro F;Jenkinson M;Bangerter NK;Andersson JLR;Griffanti L;Douaud G;Sotiropoulos SN;Jbabdi S;Hernandez-Fernandez M;Vallee E;Vidaurre D;Webster M;McCarthy P;Rorden C;Daducci A;Alexander DC;Zhang H;Dragonu I;Matthews PM;Miller KL;Smith SM
• 通讯作者: Smith SM

OPTIMISE: MS study protocol: a pragmatic, prospective observational study to address the need for, and challenges with, real world pharmacovigilance in multiple sclerosis.

• DOI: 10.1136/bmjopen-2021-050176
• 发表时间: 2021-11-25
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Dobson R;Craner M;Waddingham E;Miller A;Cavey A;Webb S;Hemingway C;Hobart J;Evangelou N;Scolding N;Rog D;Nicholas R;Marta M;Blain C;Young CA;Ford HL;Matthews PM
• 通讯作者: Matthews PM