MRC-BHF Cardiovascular Stem Cell Research Strategic Development Grant

MRC-BHF 心血管干细胞研究战略发展补助金

• 批准号: G0901467/1
• 负责人: Michael Schneider
• 金额: $ 129.51万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0901467%2F1
• 关键词: MRC; BHF; Cardiovascular; Stem; Cell

Heart muscle does not grow back following a heart attack. For this reason, a stem cell approach to regenerate the heart is attractive. We focus on using embryonic stem cells (primitive cells with the ability to become every cell type desired) or a rare and unexpected stem cell we discovered, which exists in heart muscle itself. These experiments are aimed at solving several fascinating and important problems. Where do these cardiac stem cells come from during life, and what do they become in healthy and diseased hearts? Can we improve their number or function to enhance the repair and regeneration of the heart? What specific genes and connections of genes control cardiac muscle creation? Using advanced robotic methods that test hundreds or thousands of conditions, and advanced genetic methods that measure every gene in the cells, we will study which genes are active in heart-forming cells and which are important for the cells function.

心脏病发作后，心肌不会重新生长。因此，干细胞再生心脏的方法很有吸引力。我们专注于使用胚胎干细胞（能够变成每种所需细胞类型的原始细胞）或我们发现的一种罕见且意想不到的干细胞，它存在于心肌本身中。这些实验旨在解决几个有趣且重要的问题。这些心脏干细胞在生命过程中从何而来？它们在健康和患病的心脏中会变成什么？我们能否改善它们的数量或功能来增强心脏的修复和再生？哪些特定基因和基因连接控制心肌的形成？使用先进的机器人方法来测试数百或数千种条件，以及先进的遗传方法来测量细胞中的每个基因，我们将研究哪些基因在心脏形成细胞中活跃，哪些基因对细胞功能很重要。