BHF Imperial Cardiovascular Regenerative Medicine Centre

BHF帝国心血管再生医学中心

• 批准号: MR/L012618/1
• 负责人: Sian Harding
• 金额: $ 91.05万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FL012618%2F1
• 关键词: BHF; Imperial; Cardiovascular; Regenerative; Medicine

The BHF UK Regenerative Medicine Centre at Imperial College and Nottingham focuses on the heart muscle cell, and there are two main aspects to the research. First, patient-derived blood or skin cells can be turned into beating heart muscle cells, and it has been shown that they can have the characteristics of the heart disease seen in the patient. This allows us to investigate them as a "disease-in-a-dish" model and work out drug treatments or gene therapy specific for that type of patient. One very useful aspect of the stem cells is the ability to grow them in large numbers. To take advantage of that, new machines are being developed to screen multiple cells simultaneously. Both Imperial and Nottingham have experience in designing these large-scale experiments. We wish to purchase a number of state-of-the-art machines, shared between Imperial and Nottingham; develop cell models and assays for these; then make them available to the Regenerative Medicine community. Second, we aim to make muscle grafts from the stem cell-derived heart cells and to implant them in disease models in rats and mice to assess whether they will provide repair. We have used an MRI machine to do this previously, but ours has been decommissioned. We are asking for a contribution to the purchase of another MRI, and for its housing at Imperial in the building where the majority of Cardiovascular Regenerative Medicine researchers work, and next to other imaging machines which we will also use.

位于帝国理工学院和诺丁汉的BHF英国再生医学中心专注于心肌细胞，研究主要有两个方面。首先，来自患者的血液或皮肤细胞可以转化为跳动的心肌细胞，并且已经证明它们可以具有在患者身上看到的心脏病特征。这使我们能够将它们作为“盘子里的疾病”模型进行研究，并针对这类患者制定出药物治疗或基因治疗方案。干细胞的一个非常有用的方面是它们能够大量生长。为了利用这一点，人们正在开发新的机器来同时筛选多个细胞。帝国理工大学和诺丁汉大学都有设计这些大规模实验的经验。我们希望购买一些最先进的机器，由帝国和诺丁汉共享；开发细胞模型和检测方法；然后将它们提供给再生医学界。其次，我们的目标是将干细胞来源的心脏细胞制成肌肉移植物，并将其植入大鼠和小鼠的疾病模型中，以评估它们是否会提供修复。我们以前用过核磁共振成像仪，但我们的已经退役了。我们请求捐款购买另一台核磁共振仪，并将其安置在帝国理工学院大多数心血管再生医学研究人员工作的大楼里，并在我们也将使用的其他成像设备旁边。

项目成果

Mixed-methods process evaluation of a residence-based SARS-CoV-2 testing participation pilot on a UK university campus during the COVID-19 pandemic.

• DOI: 10.1186/s12889-022-13792-8
• 发表时间: 2022-08-02
• 期刊: BMC public health
• 影响因子: 4.5

Heart regeneration.

• DOI: 10.1038/nature10147
• 发表时间: 2011-05-19
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Laflamme, Michael A.;Murry, Charles E.
• 通讯作者: Murry, Charles E.

G-protein Coupled Receptor Signaling in Pluripotent Stem Cell-derived Cardiovascular Cells: Implications for Disease Modeling.

• DOI: 10.3389/fcell.2015.00076
• 发表时间: 2015
• 期刊: Frontiers in cell and developmental biology
• 影响因子: 5.5
• 作者: Dolatshad NF;Hellen N;Jabbour RJ;Harding SE;Földes G
• 通讯作者: Földes G

Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform.

人类多能干细胞的心肌细胞：从实验室好奇心到工业生物医学平台。

• DOI: 10.1016/j.bbamcr.2015.10.014
• 发表时间: 2016-07
• 期刊: Biochimica et biophysica acta
• 作者: Denning C;Borgdorff V;Crutchley J;Firth KS;George V;Kalra S;Kondrashov A;Hoang MD;Mosqueira D;Patel A;Prodanov L;Rajamohan D;Skarnes WC;Smith JG;Young LE
• 通讯作者: Young LE