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CLINICAL PHENOMENA IN SCHIZOPHRENIA--QUANTIFICATION IN A EFFORT TO SUBTYPE

CLINICAL PHENOMENA IN SCHIZOPHRENIA--QUANTIFICATION IN A EFFORT TO SUBTYPE
精神分裂症的临床现象——量化亚型
批准号:
3968571
负责人:
C N KARSON
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
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中文摘要
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英文摘要
Despite wide variations in the clinical manifestations of schizophrenia, it remains difficult for clinicians to design novel treatments or predict vulnerability to negative outcomes (including medication side effects) based on signs and symptoms of the disorder. By focusing on certain clinical characteristics of schizophrenia we have designed a series of experimental medication treatments. This involves the notion that the disorder is associated with impaired cognitive performance. Hence, we have begun trials of medication that may improve cognition. Our first such trial utilized DDAVP with at least modest success. In addition we have looked for clinical manifestations potentially associated with poor outcomes. We have found that patients with schizophrenia are more assaultive than other seriously ill psychiatric patients while in the hospital and that a previous history of assaultive is associated with an increased number of hospitalizations. With regards to the major side effect of neuroleptic treatment, tardive dyskinesia (TD), we have found that depression may be associated with a more severe variant.
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BRAIN ELECTRICAL ACTIVITY MAPPING IN NEUROPSYCHIATRIC PATIENTS
CLINICAL PHENOMENA IN SCHIZOPHRENIA--QUANTIFICATION IN A EFFORT TO SUBTYPE
CLINICAL PHENOMENA IN SCHIZOPHRENIA AND DEVELOPMENT OF NOVEL TREATMENTS
BRAIN ELECTRICAL ACTIVITY MAPPING IN NEUROPSYCHIATRIC PATIENTS
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