To investigate the causal roles of environmental factors and viruses on exacerbations of COPD

调查环境因素和病毒对 COPD 恶化的因果作用

• 批准号: G0902135/1
• 负责人: Jennifer Quint
• 金额: $ 105.04万
• 依托单位: London School of Hygiene & Tropical Medicine
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0902135%2F1
• 关键词: investigate; causal; roles; environmental; factors

Chronic obstructive pulmonary disease (COPD) is a common lung condition most often caused by smoking. Many patients suffer from repeated flare-ups of COPD caused by chest infections. These infections are commonly caused by viruses and are important to treat and ideally prevent. Infections contribute to worsening symptoms of the disease and there is insufficient information about susceptibility to viruses to prevent chest infections or hospital admissions from happening. This study will investigate the environmental factors such as pollution and temperature on viruses circulating in the community on every day symptoms and likelihood of catching infections in COPD. Nationally this will be studied using large central databases and then more detailed study will be done at an individual patient level. This information will be of benefit to both patients and health care providers by helping to improve the organisation of health care resources, particularly in the winter and highlight times when patients should be aware of increased symptoms and viral infections. With the future development of new antiviral treatments for COPD infections this information will also help provide information as to when these drugs should be given to maximal effect.

慢性阻塞性肺疾病(COPD)是一种常见的肺部疾病，最常由吸烟引起。许多患者因胸部感染而反复发作慢性阻塞性肺疾病。这些感染通常是由病毒引起的，对治疗和理想情况下的预防都很重要。感染加剧了这种疾病的症状，而且没有足够的关于病毒易感性的信息来防止胸腔感染或住院的发生。这项研究将调查环境因素，如污染和温度对每天在社区中传播的病毒的症状和感染COPD的可能性。在全国范围内，这将使用大型中央数据库进行研究，然后将在单个患者层面进行更详细的研究。这些信息将有助于改善卫生保健资源的组织，特别是在冬季，并突出患者应该意识到症状增加和病毒感染的时间，从而对患者和卫生保健提供者都有好处。随着未来针对COPD感染的新的抗病毒治疗的发展，这些信息也将有助于提供关于何时应该给予这些药物最大效果的信息。