Selective targeting of synapses to specific dendritic locations and their modulation by voltage-gated channels

突触选择性靶向特定树突位置及其通过电压门控通道的调制

• 批准号: G1000629/1
• 负责人: Alex Thomson
• 金额: $ 190.85万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1000629%2F1
• 关键词: Selective; targeting; synapses; specific; dendritic

The neocortex is the part of the brain that has expanded most dramatically in size and complexity in parallel with the development of human intellectual abilities. Here, countless thousands of pieces of information about our own bodies and the world around us are integrated and processed to generate perceptions and memories and to initiate appropriate responses. These pieces of information arrive from all over the nervous system as electrical signals. These electrical signals are transferred from one nerve cell, or neurone, to another via tiny chemical signals that in turn generate electrical and chemical events in each follower neurone. The receiving neurones are often very complex, in their shapes and in their electrical and chemical properties. Each one is made up of many different compartments into which information can be channelled. The properties of these different compartments, the way that events in them interact with events in other compartments and how they work together to transform the many different pieces of information that constantly bombard each neurone, into the output of that cell, is the subject of this project. We focus particularly on properties that are affected in neurological diseases such as the several different types of epilepsy, in some cases as the possible cause, in others as the brain?s response to another change or insult.

新皮层是大脑的一部分，随着人类智力的发展，它在大小和复杂性上都有了最显著的扩展。在这里，关于我们自己的身体和我们周围的世界的无数信息被整合和处理，以产生感知和记忆，并启动适当的反应。这些信息以电信号的形式从神经系统各处传来。这些电信号通过微小的化学信号从一个神经细胞或神经元传递到另一个神经细胞或神经元，这些化学信号反过来又在每个跟随神经元中产生电和化学事件。接收神经元通常非常复杂，无论是在形状上，还是在电学和化学性质上。每一个都是由许多不同的隔间组成的，信息可以通过这些隔间传递。这些不同隔室的特性，它们中的事件与其他隔室中的事件相互作用的方式，以及它们如何协同工作，将不断轰击每个神经元的许多不同信息片段转化为该细胞的输出，是该项目的主题。我们特别关注神经系统疾病中受影响的特性，例如几种不同类型的癫痫，在某些情况下是可能的原因，在其他情况下是大脑？对另一个变化或侮辱的反应。