ASTHMA & ALLERGIC DISEASE CENTER FOR IMMUNODERMATOLOGY

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• 批准号: 3105055
• 负责人: IRMA GIGLI
• 金额: $ 17.46万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-09-01 至 1986-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3105055
• 关键词: asthma; human subject; hypersensitivity

Support is requested for the establishment and maintenance of a multidisciplinary center for the study of immunologic mechanisms which may play a role in the pathogenesis of certain cutaneous diseases. Such a center will harness the combined efforts of dermatologists, immunologists and allergists from various departments in the University of California, San Diego. This application is directed to three areas of research relevant to skin diseases: (a) Immunoregulatory mechanisms in patients with a variety of skin diseases thought to be immunologic in nature, (b) metabolic and biochemical alterations in immunologically damaged skin and (c) regulation of cell traffic in the epidermis and relation to the Langerhans cell. Because of their prevalence and relevance, the specific diseases to be studied include leukocytoclastic vasculitis, drug eruptions, urticaria and atopic dermatitis. Cutaneous phototoxic reactions mediated either by drugs or by endogenous phototoxic chemicals (prophyrias) offer excellent models to study tissue damage produced by activation of the complement system and the subsequent release of chemical mediators. The question of whether Langerhans cells have a "trophic" function for lymphoid cells will be investigated. Its role in vivo will be evaluated by assessing its involvement in a variety of skin diseases in which a cell-mediated immunologic mechanism seems to be involved. These studies may help not only to further our knowledge in this area, but will serve in the development of new therapeutic approaches.

请求支持建立和维持一个 免疫机制研究多学科中心 在某些皮肤疾病的发病机制中发挥作用。 这样一个 中心将利用皮肤科医生、免疫学家的共同努力 以及来自加州大学各系的过敏症专家， 圣地亚哥。 该应用程序针对三个研究领域 与皮肤病相关： (a) 患者的免疫调节机制 患有各种被认为本质上是免疫性的皮肤病，(b) 免疫受损皮肤的代谢和生化改变 (c) 表皮细胞交通的调节及其与 朗格汉斯细胞。 由于其普遍性和相关性，具体疾病 研究包括白细胞破碎性血管炎、药疹、荨麻疹和 特应性皮炎。 由药物或内源性介导的皮肤光毒性反应 光毒性化学品（prophyrias）为研究组织提供了优秀的模型 补体系统激活和随后的反应所产生的损伤 化学介质的释放。 朗格汉斯细胞是否存在的问题 对淋巴细胞具有“营养”功能的研究将被研究。 它是 体内作用将通过评估其参与各种 细胞介导的免疫机制似乎与皮肤疾病有关 涉及。 这些研究不仅有助于加深我们在这方面的知识 领域，但将有助于开发新的治疗方法。