ASTHMA & ALLERGIC DISEASE CENTER FOR IMMUNODERMATOLOGY

请求提供支助，以建立和维持一个 免疫机制研究多学科中心， 在某些皮肤疾病的发病机制中起作用。 这样的 该中心将利用皮肤科医生，免疫学家， 以及来自加州大学各个系的过敏症专家， 圣地亚哥 本申请针对三个研究领域 （a）患者的免疫调节机制 具有被认为是免疫性的多种皮肤病，（B） 免疫受损皮肤的代谢和生化改变， (c)表皮细胞运输的调节及其与 朗格汉斯细胞。 由于这些疾病的流行和相关性， 研究包括白细胞破碎性血管炎、药疹、荨麻疹和 特应性皮炎 药物或内源性药物介导的皮肤光毒性反应 光毒性化学物质（光毒性化合物）为研究组织提供了极好的模型 由补体系统激活和随后的 释放化学介质。 朗格汉斯细胞是否 对淋巴样细胞具有“营养”功能。 其 体内作用将通过评估其参与各种 皮肤病，其中细胞介导的免疫机制似乎是 涉案 这些研究不仅可以帮助我们进一步了解这一点， 该领域，但将有助于开发新的治疗方法。

Support is requested for the establishment and maintenance of a multidisciplinary center for the study of immunologic mechanisms which may play a role in the pathogenesis of certain cutaneous diseases. Such a center will harness the combined efforts of dermatologists, immunologists and allergists from various departments in the University of California, San Diego. This application is directed to three areas of research relevant to skin diseases: (a) Immunoregulatory mechanisms in patients with a variety of skin diseases thought to be immunologic in nature, (b) metabolic and biochemical alterations in immunologically damaged skin and (c) regulation of cell traffic in the epidermis and relation to the Langerhans cell. Because of their prevalence and relevance, the specific diseases to be studied include leukocytoclastic vasculitis, drug eruptions, urticaria and atopic dermatitis. Cutaneous phototoxic reactions mediated either by drugs or by endogenous phototoxic chemicals (prophyrias) offer excellent models to study tissue damage produced by activation of the complement system and the subsequent release of chemical mediators. The question of whether Langerhans cells have a "trophic" function for lymphoid cells will be investigated. Its role in vivo will be evaluated by assessing its involvement in a variety of skin diseases in which a cell-mediated immunologic mechanism seems to be involved. These studies may help not only to further our knowledge in this area, but will serve in the development of new therapeutic approaches.