ASTHMA & ALLERGIC DISEASE CENTER FOR IMMUNODERMATOLOGY

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• 批准号: 3105057
• 负责人: IRMA GIGLI
• 金额: $ 32.4万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-09-01 至 1991-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3105057
• 关键词: human subject; hypersensitivity; skin hypersensitivity; urticaria

Continuation of support is requested for a multidisciplinary center to study the basic pathologic mechanisms of certain skin diseases which appear to have the participation of humoral or cellular immunologic events, either as a primary or secondary manifestation. The center will concentrate in studies of: 1. Diseases within the spectrum of cutaneous vasculitis-angioedema-urticaria. In these studies we will attempt to identify the biochemical mediators and cellular interactions that may be responsible for the clinical manifestations in this group of diseases. 2. Receptors in patients presenting with clinical manifestations within the spectrum of altered immunologic reactivity. These studies will involve patients with: acquired deficiency syndrome, lupus erythematosus and Hansen's disease. It is proposed that complement receptors may be predictive markers of disease activity. 3. Phototoxic reactions either due to genetic defects in phorphyrin metabolism or intake of medications. These diseases offer an excellent model for studies of non-immunologic activation of the complement system and mast cell derived mediators.

请求继续为一个多学科中心提供支持，以 研究某些皮肤病出现的基本病理机制 有体液或细胞免疫事件的参与， 作为主要或次要的表现。中心将集中在 以下方面的研究： 1.皮肤科疾病 脉管炎--血管性水肿性--荨麻疹。在这些研究中，我们将尝试 确定生化介质和细胞相互作用可能是 对这组疾病的临床表现负责。 2.出现临床症状的患者体内的受体 免疫反应性改变的光谱。这些研究将涉及 患者：获得性虚弱综合征、红斑狼疮和 汉森氏病。有人认为补体受体可能是 疾病活动性的预测性标记。 3.由于卟啉基因缺陷而引起的光毒反应 新陈代谢药物的代谢或摄入这些疾病提供了一种极好的 补体系统非免疫性激活的研究模型 和肥大细胞衍生的介质。