PATHOPHYSIOLOGIC, BIOCHEMICAL CHANGES OF THERMAL INJURY

液体和电解质转移机制的研究，旷日持久 红细胞破坏、心脏(高、低)功能及其鉴定 关于严重烧伤后免疫球蛋白抑制物质的研究 承担了。 跨膜电位和微肌电解质的连续测定 分析结合代谢平衡研究在热损伤患者中进行。 损伤超过35%总体表面积(TBSA)的患者。方法 正在开发用于快速测定可交换钠质量和 为研究电解液运输机制而建立的动物模型 异常现象。红细胞破坏已被确认为由有毒物质引起 开始了对游离脂肪酸水平和脂肪代谢的研究。目前 动员脂肪的脂蛋白代谢和肝脏代谢 由三室模型的发展所追求的氧化研究 高密度脂蛋白代谢与肝细胞培养的作用 肉碱和HMG-Ac活性。几内亚40%的TBSA烫伤猪有 是为未来研究心肌异常和 营养和脂肪代谢方面的治疗性干预。提纯 层析技术已经完成，用于分离 与α-球蛋白相关的免疫抑制因子 在淋巴细胞和白细胞的体外模型上进行测试。

Studies of the mechanisms of fluid and electrolyte translocation, protracted erythrocyte destruction, cardiac (hyper- and hypo-) function and identification of immunoglobulin-suppressive substance following major burn injury are being undertaken. Serial measurements of transmembrane potentials (TM) and micromuscle electrolyte analysis coupled with metabolic balance studies are done in thermally injured patients with injuries exceeding 35% total body surface area (TBSA). Methods are being developed for rapid determination of exchangeable sodium mass and animal models developed for study of the mechanism of electolyte transport abnormalities. Erythrocyte destruction has been identified as produced by toxic levels of free fatty acids and studies of fat metabolism initiated. Currently lipoprotein metabolism and liver metabolism of mobilized adipose is being pursued by the development of a three compartment model for oxidation studies of high density lipoprotein metabolism and hepatcyte culture for the role of carnitine and HMG-Ac activity. Forty percent TBSA scald burn in guina pigs have been developed for the future study of the myocardial abnormalities and therapeutic interventions in nutrition and metabolism of fat. Purification chromatography techniques have been accomplished for the isolation of alpha-globulin associated immunosuppressive factors which are currently being tested on a lymphocyte and leukocyte in vitro model.