Designer RNA-binding proteins for research and therapeutic purposes

用于研究和治疗目的的设计 RNA 结合蛋白

• 批准号: nhmrc : 632757
• 负责人: A/Pr David Segal
• 金额: $ 37.17万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/designer-rna-binding-therapeutic-purposes/97843
• 关键词: Designer; RNA; binding; proteins; research

It has become clear recently that ribonucleic acids play many roles in the switching on and off of genes in humans and other organisms. These molecules play roles in a number of diseases, including HIV-AIDS, hepatitis, and a large number of inherited disorders. We propose to build a library of protein molecules that can bind specifically to a wide range of RNA targets and modulate their function. These molecules have the capacity to act as therapeutics for a wide range of diseases.

最近人们已经清楚，核糖核酸在人类和其他生物体基因的开启和关闭中发挥着许多作用。这些分子在许多疾病中发挥作用，包括艾滋病毒/艾滋病、肝炎和大量遗传性疾病。我们建议建立一个蛋白质分子库，可以特异性结合到广泛的RNA靶点，并调节它们的功能。这些分子有能力作为治疗多种疾病的药物。