Designer RNA-binding proteins for research and therapeutic purposes

最近已经很清楚，核糖核酸在人类和其他生物体的基因开关中扮演着许多角色。这些分子在许多疾病中发挥作用，包括艾滋病毒-艾滋病、肝炎和大量遗传性疾病。我们建议建立一个蛋白质分子文库，可以与广泛的RNA靶标特异结合并调节它们的功能。这些分子具有治疗多种疾病的能力。

It has become clear recently that ribonucleic acids play many roles in the switching on and off of genes in humans and other organisms. These molecules play roles in a number of diseases, including HIV-AIDS, hepatitis, and a large number of inherited disorders. We propose to build a library of protein molecules that can bind specifically to a wide range of RNA targets and modulate their function. These molecules have the capacity to act as therapeutics for a wide range of diseases.