Do transcription factor-RNA interactions represent a new mechanism of gene regulation?

这项提议的目的是研究基因开启和关闭的机制。我们假设，转录因子，一组与DNA接触以调节基因的蛋白质，也可以与另一类被称为RNA的分子相互作用。了解基因是如何开启和关闭的，是以理性的方式设计抗击多种疾病的策略的核心。我们的工作将对生物技术和基因治疗产生影响。

The aim of this proposal is to investigate the mechanisms through which genes are switched on and off. We hypothesise that transcription factors, a set of proteins that contacts DNA to regulate genes, can also interact with a separate class of molecules known as RNA. An understanding of how genes are switched on and off is central to devising strategies for fighting many diseases in a rational way. Our work will have implications for biotechnology and gene therapy.