Do transcription factor-RNA interactions represent a new mechanism of gene regulation?

转录因子-RNA相互作用是否代表了一种新的基因调控机制？

• 批准号: nhmrc : GNT1063188
• 负责人: A/Pr David Segal
• 金额: $ 45.36万
• 依托单位: University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transcription-factor-rna-gene-regulation/1344834
• 关键词: Do; transcription; factor; RNA; interactions

The aim of this proposal is to investigate the mechanisms through which genes are switched on and off. We hypothesise that transcription factors, a set of proteins that contacts DNA to regulate genes, can also interact with a separate class of molecules known as RNA. An understanding of how genes are switched on and off is central to devising strategies for fighting many diseases in a rational way. Our work will have implications for biotechnology and gene therapy.

这项提议的目的是研究基因开启和关闭的机制。我们假设转录因子，一组与DNA接触以调节基因的蛋白质，也可以与另一类被称为RNA的分子相互作用。了解基因是如何开启和关闭的，对于制定合理的对抗多种疾病的策略至关重要。我们的工作将对生物技术和基因治疗产生影响。