MRC Centre for Reproductive Health

MRC 生殖健康中心

• 批准号: G1002033/1
• 负责人: Jeffrey Pollard
• 金额: $ 243.82万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1002033%2F1
• 关键词: MRC; Centre; Reproductive; Health

Reproduction is a fundamental feature of all life, essential for the continuation of our species. The birth of a healthy baby represents the culmination of a remarkable series of events and a defining moment in our progress towards ?living a long and healthy life?. The reproductive tissues that provide the platform for our fertility and nurture a successful pregnancy are characterised by their remarkable ?resilience? ? namely their ability to withstand or recover quickly from ?challenges? that might otherwise have an adverse impact on their function. Other tissues cannot usually show such resilience. Our new Centre will link scientists studying the ways in which reproductive tissues regenerate, repair and renew themselves enabling them to withstand the impacts of our modern lifestyle including stress and obesity, with teams of doctors and scientists who are focusing their research on stem cell biology, tissue regeneration, inflammation and fetal growth in the brain, liver, lung and kidney. This multidisciplinary approach will ensure we can apply our research findings to the development of new therapies for common reproductive problems such as infertility, heavy periods, premature birth, low birth weight, but also that they are applied towards therapies for diseases that affect the liver, brain, lung and vascular system such as cirrhosis and cancer. Crucially, we will train the next generation of basic and clinician scientists in reproductive medicine and its broader exploitation and communicate our new and exciting research findings to the general public, through our public lecture and schools outreach programmes.

繁殖是所有生命的基本特征，对我们物种的延续至关重要。一个健康婴儿的诞生代表着一系列非凡事件的高潮，也是我们迈向未来的决定性时刻。健康长寿吗？生殖组织为我们的生育能力提供了平台，并培育了一个成功的怀孕，其特点是显着的？恢复力？?也就是他们承受或快速恢复的能力？挑战？否则可能对其职能产生不利影响。其他组织通常不能表现出这样的弹性。我们的新中心将连接科学家研究生殖组织再生，修复和自我更新的方式，使他们能够承受我们现代生活方式的影响，包括压力和肥胖，与医生和科学家团队谁是专注于干细胞生物学，组织再生，炎症和胎儿生长的研究在大脑，肝脏，肺和肾脏。这种多学科的方法将确保我们能够将我们的研究成果应用于开发新的治疗方法，用于治疗常见的生殖问题，如不孕症，月经过多，早产，低出生体重，而且它们也适用于治疗影响肝脏，大脑，肺和血管系统的疾病，如肝硬化和癌症。至关重要的是，我们将在生殖医学及其更广泛的利用方面培训下一代基础和临床科学家，并通过我们的公开讲座和学校外联方案，向公众传达我们新的和令人兴奋的研究成果。