IMMUNOLOGY OF FOUR TROPICAL PARASITIC DISEASES OF MAN

本项目为一个热带病研究单位提出了四项研究 在发展中国家流行的寄生虫病。二、利什曼病 和南美锥虫病，是由原弓形虫引起的，丝虫病和 血吸虫病是由蠕虫引起的。目前的提案采取了 研究这些疾病的免疫学方法。 重点是描述和分离诱导产生 使用由淋巴细胞杂交体产生的单抗的保护性免疫。 这些抗原将被用于开发特定的诊断测试，并最终 疫苗。对保护性免疫机制的研究应有助于 后者的产生，以及关于免疫病理学的那些应该导致采取措施 预防感染的后果。 在利什曼项目中，重点是描述特定物种。 新大陆流行的生物体抗原及其相互作用 不同种类的利什曼原虫与激活的人巨噬细胞。在 丝虫病项目，除了阶段特异性抗原和 免疫机制和免疫病理，有相互作用的研究 含有凝血因子和血小板的蠕虫。在锥虫病中 PROJECT，细胞免疫参与杀死血液的机制 重点介绍了克氏毛滴虫的溪流形态。在血吸虫病项目中，强调 致力于研究导致血吸虫表面变化的 免疫逃避和由免疫攻击引起的逃避；研究还包括 提出了嗜酸性粒细胞介导的杀灭幼虫的机制，并对 分离相关的靶抗原。电子显微镜上的岩心和 在形态、淋巴细胞杂交瘤和维持生命周期方面 包括在内。

This Program Project for a Tropical Disease Research Unit proposes study of four parasitic diseases that are endemic in the developing world. Two, leishmaniasis and South American trypanosomiasis, are caused by protoxoa, and filariasis and schistosomiasis are caused by helminths. The present proposal takes an immunologic approach to study of these diseases. Emphasis is placed on delineating and isolating the antigens which induced protective immunity using monoclonal antibodies produced by lymphocyte hybrids. These antigens will be used to develop specific diagnostic tests and eventually vaccines. Studies on the mechanism of protective immunity should aid in the production of the latter, and those on immunpathology should lead to measures to prevent the consequences of infection. In the leishmania project, an emphasis is placed on delineating species specific antigens from organisms prevalent in the New World and on the interaction of different species of leishmania with activated human macrophages. In the filariasis project, in addition to the studies on stage specific antigens and mechanism of immunity and immunopathology, there are studies on the interaction of worms with coagulation factors and platelets. In the trypanosomiasis project, the mechanism of cell-mediated immunity involved in killing blood stream forms of T. cruzi is stressed. In the schistosomiasis projects, emphasis is placed on studying changes on the surface of the schistosomula that lead to immune evasion and those that are caused by immune attack; studies are also proposed on the mechanism of eosinophil-mediated killing of the larvae, and on isolating relevant target antigens. Cores on electron microscopy and morphology, on lymphocyte hybridomas, and on maintaining the life cycles are included.