Exploring stromal-epithelial interactions in oesophageal cancer

探索食管癌中的基质-上皮相互作用

• 批准号: G1002565/1
• 负责人: Timothy Underwood
• 金额: $ 143.86万
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1002565%2F1
• 关键词: Exploring; stromal; epithelial; interactions; oesophageal

Cancer of the oesophagus (gullet) is becoming more common in the UK. Despite best current treatments the likelihood of cure is still very poor. The relationship between cells lining the oesophagus and the cells in the supporting layer beneath is fundamental to the development of oesophageal cancer. We make use of a specially developed model system to better understand this relationship with the aim of identifying new molecules as targets for cancer prevention and treatment. Our research uses human cells taken from biopsies of the oesophagus to grow a model oesophagus in the laboratory. Using this system we can determine the interaction between different cell types and the relative contribution that they make to cancer progression. Our overall aim is to understand the differences between cells in the supporting layer of the oesophagus at different stages of cancer growth and use these differences to design new ways of detecting and treating oesophageal cancer before it spreads.

食道癌（食道癌）在英国变得越来越常见。尽管目前有最好的治疗方法，但治愈的可能性仍然很低。食管内壁细胞与下方支撑层细胞之间的关系是食管癌发生的基础。我们利用专门开发的模型系统来更好地理解这种关系，目的是识别新分子作为癌症预防和治疗的靶标。我们的研究使用从食道活检中取出的人体细胞在实验室中培养食道模型。使用该系统，我们可以确定不同细胞类型之间的相互作用以及它们对癌症进展的相对贡献。我们的总体目标是了解食管支撑层细胞在癌症生长的不同阶段之间的差异，并利用这些差异设计在食管癌扩散之前检测和治疗食管癌的新方法。