Developmental Clinical Studies - development of vitamin D therapy to prevent acute lung injury.

这项研究的目的是开发维生素D作为一种治疗方法来预防急性肺损伤。急性肺损伤是重症患者肺功能衰竭的主要原因。大多数受影响的患者处于工作年龄，幸存者的健康相关生活质量显著下降，46%的患者在12个月内无法重返工作岗位。目前，除了有创性保护性通气外，没有任何疗法被证实可以降低幸存者的死亡率或改善功能预后。这是一项未得到满足的重大卫生需求。通过开展这项研究，我们将确定简单廉价的维生素D替代是否会影响急性肺损伤的发展和严重程度。

The aim of this research is to develop vitamin D as a therapy to prevent acute lung injury. Acute lung injury ALI is a major cause of lung failure in critically ill patients. Most patients affected are of working age and survivors experience a significant reduction in health-related quality of life, with 46% unable to return to work within 12 months. Currently, apart from invasive protective ventilation, no therapy has been conclusively proven to reduce mortality or improve functional outcome in survivors. This represents a major unmet health need. By undertaking this research we will establish if simple and cheap replacement of vitamin D influences the development and severity of acute lung injury.