Developmental Clinical Studies - development of vitamin D therapy to prevent acute lung injury.

发育临床研究 - 开发维生素 D 疗法以预防急性肺损伤。

• 批准号: G1100196/1
• 负责人: David Thickett
• 金额: $ 62.53万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1100196%2F1
• 关键词: Developmental; Clinical; Studies; development; vitamin

The aim of this research is to develop vitamin D as a therapy to prevent acute lung injury. Acute lung injury ALI is a major cause of lung failure in critically ill patients. Most patients affected are of working age and survivors experience a significant reduction in health-related quality of life, with 46% unable to return to work within 12 months. Currently, apart from invasive protective ventilation, no therapy has been conclusively proven to reduce mortality or improve functional outcome in survivors. This represents a major unmet health need. By undertaking this research we will establish if simple and cheap replacement of vitamin D influences the development and severity of acute lung injury.

本研究的目的是开发维生素 D 作为预防急性肺损伤的疗法。急性肺损伤ALI是危重患者肺衰竭的主要原因。大多数受影响的患者处于工作年龄，幸存者的健康相关生活质量显着下降，46% 的患者无法在 12 个月内重返工作岗位。目前，除了有创保护性通气外，没有任何治疗方法被最终证明可以降低幸存者的死亡率或改善功能结果。这是一个重大的未满足的健康需求。通过开展这项研究，我们将确定简单且廉价的维生素 D 替代品是否会影响急性肺损伤的发展和严重程度。