Characterisation of the bacterial proteins YjeE, YeaZ and YgjD and evaluation as a potential novel antimicrobial target

细菌蛋白 YjeE、YeaZ 和 YgjD 的表征以及作为潜在新型抗菌靶点的评估

• 批准号: G1100376/1
• 负责人: James Cargill
• 金额: $ 25.26万
• 依托单位: University of Dundee
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G1100376%2F1
• 关键词: Characterisation; bacterial; proteins; YjeE; YeaZ

Bacteria have a number of proteins that are not found in any other form of life, and some of these have been shown to be essential for bacteria to survive. This project aims to explore the way a set of three essential bacterial proteins interact with each other and to try to understand the critical roles that they play within the bacterium. Armed with this knowledge we would then like to discover small molecules that disrupt these processes, which might be ultimately developed as new drugs to treat bacterial infections.Antibiotic resistance in bacteria is increasing, and with it the number of hard-to-treat infections also increases. The network of proteins we will investigate is not attacked by the antibiotic agents we currently use, and so may be a potential target for new antibiotic agents that may be effective when the bacteria are resistant to out current antibiotics.

细菌具有许多在任何其他形式的生命中都没有发现的蛋白质，其中一些已被证明是细菌生存所必需的。该项目旨在探索一组三种基本细菌蛋白质相互作用的方式，并试图了解它们在细菌中发挥的关键作用。有了这些知识，我们就可以发现能够破坏这些过程的小分子，这些小分子最终可能被开发成治疗细菌感染的新药。细菌对抗生素的耐药性正在增加，难以治疗的感染数量也随之增加。我们将研究的蛋白质网络不会受到我们目前使用的抗生素的攻击，因此可能是新抗生素的潜在靶点，当细菌对现有抗生素具有耐药性时，新抗生素可能有效。