Detecting bioactivity in a naturally-occurring aggrecan fragment

检测天然存在的聚集蛋白聚糖片段的生物活性

• 批准号: nhmrc : 628475
• 负责人: Dr Fraser Rogerson
• 金额: $ 27.18万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/detecting-bioactivity-naturally-aggrecan-fragment/97317
• 关键词: Detecting; bioactivity; naturally; occurring; aggrecan

The dynamic balance of anabolic and catabolic processes in healthy cartilage is disturbed in arthritis, with increased catabolism leading to irreparable cartilage damage. We will study the ability of a naturally-occuring aggrecan fragment to modulate cartilage catabolism. Our in vitro and in vivo experiments suggest that the aggrecan fragment limits cartilage destruction. This study tests our hypothesis that the aggrecan fragment antagonises cartilage damage and promote cartilage repair.

健康软骨中合成代谢和分解代谢过程的动态平衡在关节炎中被扰乱，增加的catalysts导致不可修复的软骨损伤。我们将研究自然发生的聚集蛋白聚糖片段调节软骨catalysis的能力。我们的体外和体内实验表明，聚集蛋白聚糖片段限制软骨破坏。这项研究验证了我们的假设，即聚集蛋白聚糖片段拮抗软骨损伤并促进软骨修复。