ADAMTS-5 activity and the effect of a dominant-negative mutant

ADAMTS-5 活性和显性失活突变体的影响

• 批准号: nhmrc : 607343
• 负责人: Dr Fraser Rogerson
• 金额: $ 36.02万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/adamts-5-activity-negative-mutant/82850
• 关键词: ADAMTS; activity; effect; dominant; negative

Cartilage loss is a feature of arthritis and is caused by enzymes. We discovered that loss of a critical cartilage component is caused by the enzyme ADAMTS-5. We also discovered that a mutant form of ADAMTS-5 blocks the normal emzyme, possibly by a novel binding interaction. If we can understand how this interaction works, we can exploit it for the design of new arthritis therapies. This project aims to identify the novel interaction and improve out understanding of cartilage destruction.

关节炎的一个特征是关节炎的关节炎。我们发现，一个关键的软骨成分的损失是由酶ADAMTS-5引起的。我们还发现ADAMTS-5的突变形式可能通过一种新的结合相互作用阻断正常的酶。如果我们能够理解这种相互作用是如何起作用的，我们就可以利用它来设计新的关节炎疗法。该项目旨在确定新的相互作用，并提高我们对软骨破坏的理解。