EXPERIMENTAL AND CLINICAL PHARMACOGENETICS

药物代谢和毒性的药物遗传学研究计划 药物和其他环境化学品的影响。 调查 将在人类家庭中进行，在基因定义的实验中， 动物模型和人类和动物组织的亚细胞系统。 这 是一个跨学科的项目， 以及人类和老鼠的遗传学，并延伸到生物化学， 毒理学和分子生物学。 具体来说，该计划将进行1）研究，以确定 快速和慢速同工酶差异的结构和功能性质 乙酰化剂N-乙酰基转移酶; 2）实验和临床研究， 确定人血清酯酶的意义和关系， 有机磷毒性和药物代谢; 3）分子生物学 (gene克隆）研究，以确定是否遗传差异， 通常的人血清胆碱酯酶及其同工酶变体是 这是由DNA多态性造成的

A program of pharmacogenetic investigation in drug metabolism, and toxicity of drugs and other environmental chemicals is proposed. The investigations will be performed in human families, in genetically defined experimental animal models, and subcellular systems of human and animal tissues. This is an interdisciplinary program combining investigators from pharmacology and human and mouse genetics with extensions into biological chemistry, toxicology and molecular biology. Specifically, the program will undertake 1) studies to determine the structural and functional nature of isozymic differences of rapid and slow acetylator N-acetyltransferases; 2) experimental and clinical studies to determine the significance and relationship of human serum esterases to organophosphate toxicity and drug metabolism; and 3) molecular biology (gene cloning) studies to determine whether the hereditary difference in the usual human serum cholinesterase and its isozymic variants are accounted for by DNA polymorphisms.