COMPUTATIONAL GENOMICS ANALYSIS AND TRAINING (CGAT)AT THE MRC FUNCTIONAL GENOMICS UNIT

MRC 功能基因组学单元的计算基因组学分析和培训 (CGAT)

• 批准号: MC_EX_G1000902
• 负责人: Chris Ponting
• 金额: $ 316.69万
• 依托单位: MRC Harwell Institute
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_EX_G1000902
• 关键词: COMPUTATIONAL; GENOMICS; ANALYSIS; TRAINING; CGAT

CGAT's mission will be to reveal the significance of high-throughput sequence in health and disease, whilst providing training opportunities for pre- and post-doctoral scientists. The Programme will provide access to genome analysis for those UK biologists and clinicians who are less used to managing, manipulating and analysing extremely large sequence data sets. CGAT will take advantage of the analytical expertise readily available both from within the MRC Functional Genomics Unit, and from strong interactions with others in the UK genomics research community. The Strategic Programme will aim both to fulfil the promise of high-throughput genome data in answering the most important questions in genetics and human disease, and to train a new generation of genomics researchers.

CGAT的使命是揭示高通量序列在健康和疾病中的重要性，同时为博士后和博士后科学家提供培训机会。该项目将为那些不太习惯管理、操作和分析超大序列数据集的英国生物学家和临床医生提供基因组分析。cat将充分利用MRC功能基因组学部门的分析专业知识，以及与英国基因组学研究界的其他人员的密切互动。该战略规划的目标将是实现高通量基因组数据的承诺，以回答遗传学和人类疾病中最重要的问题，并培训新一代基因组学研究人员。

项目成果

Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates.

• DOI: 10.7554/elife.00348
• 发表时间: 2013-02-26
• 期刊: eLife
• 影响因子: 7.7
• 作者: Long HK;Sims D;Heger A;Blackledge NP;Kutter C;Wright ML;Grützner F;Odom DT;Patient R;Ponting CP;Klose RJ
• 通讯作者: Klose RJ

Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy.

• DOI: 10.1016/j.eururo.2013.08.011
• 发表时间: 2014-07
• 期刊: EUROPEAN UROLOGY
• 影响因子: 23.4
• 作者: Rajan, Prabhakar;Sudbery, Ian M.;Villasevil, M. Eugenia M.;Mui, Ernest;Fleming, Janis;Davis, Mark;Ahmad, Imran;Edwards, Joanne;Sansom, Owen J.;Sims, David;Ponting, Chris P.;Heger, Andreas;McMenemin, Rhona M.;Pedley, Ian D.;Leung, Hing Y.
• 通讯作者: Leung, Hing Y.

Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment.

• DOI: 10.1016/j.celrep.2014.04.012
• 发表时间: 2014-06-12
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Cooper S;Dienstbier M;Hassan R;Schermelleh L;Sharif J;Blackledge NP;De Marco V;Elderkin S;Koseki H;Klose R;Heger A;Brockdorff N
• 通讯作者: Brockdorff N

Identification of genetic variants affecting vitamin D receptor binding and associations with autoimmune disease

鉴定影响维生素 D 受体结合的遗传变异及其与自身免疫性疾病的关联

• DOI: 10.1101/080143
• 发表时间: 2016
• 作者: Gallone G

IRF5:RelA interaction targets inflammatory genes in macrophages.

• DOI: 10.1016/j.celrep.2014.07.034
• 发表时间: 2014-09-11
• 期刊: Cell reports
• 影响因子: 8.8
• 作者: Saliba DG;Heger A;Eames HL;Oikonomopoulos S;Teixeira A;Blazek K;Androulidaki A;Wong D;Goh FG;Weiss M;Byrne A;Pasparakis M;Ragoussis J;Udalova IA
• 通讯作者: Udalova IA