Establishing a healthy growth trajectory from birth: The Baby Milk Trial

建立从出生起的健康成长轨迹：婴儿奶粉试验

• 批准号: MC_EX_MR/J000361/1
• 负责人: Rajalakshmi Lakshman
• 金额: $ 98.86万
• 依托单位: MRC Centre Cambridge
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_EX_MR%2FJ000361%2F1
• 关键词: Establishing; healthy; growth; trajectory; birth

The prevalence of childhood obesity has increased rapidly over the past two decades. Excess weight in childhood tracks into adult life and causes problems both in the short term and in the long term. National surveys show that more than one in five children are already overweight (13%) or obese (10%) when they start school. Hence any efforts to prevent obesity must start early. The Foresight Report and the Healthy Weight Healthy Lives strategy have highlighted the importance of preventing childhood obesity by focussing on the early years. However, to date there is little evidence on which to develop effective preventive strategies. Infancy is a period of rapid growth and weight gain and obesity prevention during this period may be effective. Nutrition and growth during infancy may also have long term effects by altering eating behaviours and risks of obesity and obesity-related disorders in later life. UK Infant Feeding Surveys show that at birth one in three (35%) of babies receive formula-milk and this number increases to almost all babies (92%) at 6 months of age. Hence, in addition to promoting breastfeeding, it important to optimise the growth of formula-milk fed babies. Our previous research shows that parents who give their babies formula-milk as part of their everyday diet need more information and support. Researchers at the Centre for Diet and Activity Research (CEDAR) and MRC Epidemiology Unit in Cambridge have been working with mothers and healthcare professionals to develop a feeding programme which aims to avoid excess weight gain in formula-milk fed babies. The programme we have developed aims to support parents who feed their babies formula-milk to achieve a healthy pattern of growth and weight gain.The infant feeding programme will be tested in a randomised controlled trial involving 700 mothers and their babies. Half the mothers will be given advice and support to follow the new feeding programme. The other half will be given routine advice about formula-milk feeding and weaning. The growth of babies in the two groups will be compared. This comparison is important to test whether our new feeding programme is effective in preventing excess weight gain and subsequent obesity.The results of the study will help to inform infant feeding guidelines and will also help us understand the links between infant feeding, behaviour, appetite and growth.

在过去的二十年里，儿童肥胖症的流行率迅速上升。童年时期的超重会延续到成年生活，在短期和长期内都会引发问题。全国性调查显示，超过五分之一的儿童在入学时已经超重(13%)或肥胖(10%)。因此，任何预防肥胖的努力都必须及早开始。展望报告和健康体重健康生活战略强调了通过关注早年来预防儿童肥胖症的重要性。然而，到目前为止，几乎没有证据表明可以制定有效的预防战略。婴儿期是快速生长和体重增加的时期，在这一时期预防肥胖可能是有效的。婴儿期的营养和生长也可能通过改变饮食行为以及在以后的生活中患肥胖症和肥胖症相关疾病的风险而产生长期影响。英国婴儿喂养调查显示，每三个婴儿中就有一个(35%)在出生时喝配方奶，这一数字上升到几乎所有6个月大的婴儿(92%)。因此，除了促进母乳喂养外，优化配方奶喂养婴儿的生长也很重要。我们之前的研究表明，给婴儿配方奶作为日常饮食一部分的父母需要更多的信息和支持。饮食与活动研究中心(Cedar)和剑桥MRC流行病学研究所的研究人员一直在与母亲和医疗保健专业人员合作制定一项喂养计划，旨在避免配方奶喂养的婴儿体重过度增加。我们制订的计划旨在支持喂饲婴儿配方奶粉的父母达致健康的成长和体重增加模式。喂饲婴儿计划将在一项随机对照试验中进行，受试者包括700名母亲和他们的婴儿。一半的母亲将得到建议和支持，以遵循新的喂养计划。另一半将接受有关配方奶喂养和断奶的常规建议。两组婴儿的生长发育情况将进行比较。这一比较对于测试我们的新喂养计划是否有效防止体重超标和随后的肥胖非常重要。研究结果将有助于为婴儿喂养指南提供信息，也将帮助我们了解婴儿喂养、行为、食欲和生长之间的联系。

项目成果

Determinants of Change in Physical Activity in Children 0-6 years of Age: A Systematic Review of Quantitative Literature.

• DOI: 10.1007/s40279-016-0656-0
• 发表时间: 2017-07
• 期刊: Sports medicine (Auckland, N.Z.)
• 作者: Hesketh KR;O'Malley C;Paes VM;Moore H;Summerbell C;Ong KK;Lakshman R;van Sluijs EMF
• 通讯作者: van Sluijs EMF

Positive maternal attitudes to following healthy infant feeding guidelines attenuate the associations between infant appetitive traits and both infant milk intake and weight

• DOI: 10.1016/j.appet.2021.105124
• 发表时间: 2021-02-05
• 期刊: APPETITE
• 影响因子: 5.4
• 作者: Clifton, Emma A. D.;Ahern, Amy L.;Lakshman, Rajalakshmi
• 通讯作者: Lakshman, Rajalakshmi

Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration: protocol for a systematic review with individual participant data meta-analysis of behavioural interventions for the prevention of early childhood obesity.

• DOI: 10.1136/bmjopen-2020-048166
• 发表时间: 2022-01-20
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Hunter KE;Johnson BJ;Askie L;Golley RK;Baur LA;Marschner IC;Taylor RW;Wolfenden L;Wood CT;Mihrshahi S;Hayes AJ;Rissel C;Robledo KP;O'Connor DA;Espinoza D;Staub LP;Chadwick P;Taki S;Barba A;Libesman S;Aberoumand M;Smith WA;Sue-See M;Hesketh KD;Thomson JL;Bryant M;Paul IM;Verbestel V;Stough CO;Wen LM;Larsen JK;O'Reilly SL;Wasser HM;Savage JS;Ong KK;Salvy SJ;Messito MJ;Gross RS;Karssen LT;Rasmussen FE;Campbell K;Linares AM;Øverby NC;Palacios C;Joshipura KJ;González Acero C;Lakshman R;Thompson AL;Maffeis C;Oken E;Ghaderi A;Campos Rivera M;Pérez-Expósito AB;Banna JC;de la Haye K;Goran M;Røed M;Anzman-Frasca S;Taylor BJ;Seidler AL;Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration
• 通讯作者: Transforming Obesity Prevention for CHILDren (TOPCHILD) Collaboration

Toward Understanding How Social Factors Shaped a Behavioral Intervention on Healthier Infant Formula-Feeding.

了解社会因素如何影响健康婴儿配方奶喂养的行为干预。

• DOI: 10.17863/cam.22779
• 发表时间: 2018
• 作者: Guell C

Positive maternal attitudes to following healthy infant feeding guidelines attenuate the associations between infant appetitive traits and both infant milk intake and weight.

母亲对遵循健康婴儿喂养指南的积极态度会减弱婴儿食欲特征与婴儿牛奶摄入量和体重之间的关联。

• DOI: 10.17863/cam.64081
• 发表时间: 2021
• 作者: Clifton E