Rare disease use of clinical trial simulation for the chioce and optimization of study designs/Priomedchild Call/ER

罕见疾病使用临床试验模拟来选择和优化研究设计/Priomedchild Call/ER

• 批准号: MC_G1100157
• 负责人: Leon Aarons
• 金额: $ 31.36万
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2010
• 资助国家: 英国
• 起止时间: 2010 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_G1100157
• 关键词: Rare; disease; use; clinical; trial

Abstracts are not currently available in GtR for all funded research. This is normally because the abstract was not required at the time of proposal submission, but may be because it included sensitive information such as personal details.

目前GtR中并没有所有资助研究的摘要。这通常是因为在提交提案时不需要摘要，但也可能是因为摘要中包含个人详细信息等敏感信息。

项目成果

Accounting for dropout in xenografted tumour efficacy studies: integrated endpoint analysis, reduced bias and better use of animals.

考虑到异种移植肿瘤功效研究的辍学：综合终点分析，偏见减少和更好地使用动物。

• DOI: 10.1007/s00280-016-3059-x
• 发表时间: 2016-07
• 期刊: Cancer chemotherapy and pharmacology
• 影响因子: 3
• 作者: Martin EC;Aarons L;Yates JW
• 通讯作者: Yates JW

Experimental designs for small randomised clinical trials: an algorithm for choice.

• DOI: 10.1186/1750-1172-8-48
• 发表时间: 2013-03-25
• 期刊: Orphanet journal of rare diseases
• 影响因子: 3.7
• 作者: Cornu C;Kassai B;Fisch R;Chiron C;Alberti C;Guerrini R;Rosati A;Pons G;Tiddens H;Chabaud S;Caudri D;Ballot C;Kurbatova P;Castellan AC;Bajard A;Nony P;CRESim & Epi-CRESim Project Groups;Aarons L;Bajard A;Ballot C;Bertrand Y;Bretz F;Caudri D;Castellan C;Chabaud S;Cornu C;Dufour F;Dunger-Baldauf C;Dupont JM;Fisch R;Guerrini R;Jullien V;Kassaï B;Nony P;Ogungbenro K;Pérol D;Pons G;Tiddens H;Rosati A;Alberti C;Chiron C;Kurbatova P;Nabbout R
• 通讯作者: Nabbout R

What do we mean by identifiability in mixed effects models?

• DOI: 10.1007/s10928-015-9459-4
• 发表时间: 2016-02-01
• 期刊: JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
• 影响因子: 2.5
• 作者: Lavielle, Marc;Aarons, Leon
• 通讯作者: Aarons, Leon

Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions.

• DOI: 10.1208/s12248-015-9849-y
• 发表时间: 2016-03
• 期刊: The AAPS journal
• 作者: Margolskee A;Darwich AS;Galetin A;Rostami-Hodjegan A;Aarons L
• 通讯作者: Aarons L