Wellcome Trust MRC Human Inducible Pluripotent Stem Cell Initiative

Wellcome Trust MRC 人类诱导多能干细胞计划

• 批准号: MC_PC_12026
• 负责人: Fiona Watt
• 金额: $ 510.84万
• 依托单位: Wellcome Sanger Institute
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_12026
• 关键词: Wellcome; Trust; MRC; Human; Inducible

As it becomes cheaper and faster to sequence the DNA of individuals in the population we are faced with two challenges. One is to discover which aspects of the genetic variation between individuals are compatible with good health and which are linked to increased risk of specific diseases. The other is that it is not always obvious why a particular genetic mutation causes a particular disease; if we knew the answer we would be better placed to devise new ways to treat that disease. A technique that can help us meet these challenges is to make stem cells, known as induced pluripotent stem (iPS) cells, from small samples of the skin or blood of healthy and diseased individuals. By comparing the DNA of iPS cells with the way the cells behave when grown in the laboratory we can understand how variation in our DNA results in variation in cell behaviour and use this information to identify new disease mechanisms. The iPS cells and associated data that we generate will be freely available to researchers and doctors throughout the UK and will foster collaborations that will speed up the translation of research into improved diagnosis and treatment of disease.

随着对人口中个体的DNA进行测序变得更便宜和更快，我们面临着两个挑战。一个是发现个体之间遗传变异的哪些方面与健康状况相符，哪些方面与特定疾病的风险增加有关。另一个是，为什么特定的基因突变会导致特定的疾病并不总是显而易见的;如果我们知道答案，我们就能更好地设计出治疗这种疾病的新方法。一种可以帮助我们应对这些挑战的技术是从健康和患病个体的皮肤或血液的小样本中制造干细胞，称为诱导多能干细胞（iPS）。通过将iPS细胞的DNA与细胞在实验室中生长时的行为方式进行比较，我们可以了解DNA的变化如何导致细胞行为的变化，并利用这些信息来识别新的疾病机制。我们产生的iPS细胞和相关数据将免费提供给英国各地的研究人员和医生，并将促进合作，加快将研究转化为改进的疾病诊断和治疗。

项目成果

Efficiency and safety of varying the frequency of whole blood donation: randomised trial of 45,000 donors

改变全血捐献频率的效率和安全性：45,000 名捐献者的随机试验

• DOI: 10.17863/cam.13346
• 发表时间: 2017
• 作者: Di Angelantonio E

Effect of Vitamin D Supplementation on Markers of Vascular Function: A Systematic Review and Individual Participant Meta- Analysis

补充维生素 D 对血管功能标志物的影响：系统评价和个体参与者荟萃分析

• DOI: 10.17863/cam.27691
• 发表时间: 2018
• 作者: Beveridge L

Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses.

• DOI: 10.1161/circulationaha.122.060700
• 发表时间: 2022-11-15
• 期刊: CIRCULATION
• 影响因子: 37.8
• 作者: Gaziano, Liam;Sun, Luanluan;Arnold, Matthew;Bell, Steven;Cho, Kelly;Kaptoge, Stephen K.;Song, Rebecca J.;Burgess, Stephen;Posner, Daniel C.;Mosconi, Katja;Cohen, Cassianne Robinson;Mason, Amy M.;Bolton, Thomas R.;Tao, Ran;Allara, Elias;Schubert, Petra;Chen, Lingyan;Staley, James R.;Staplin, Natalie;Altay, Servet;Amiano, Pilar;Arndt, Phar Volker;Arnlov, Johan;Barr, Elizabeth L. M.;Bjorkelund, Cecilia;Boer, Jolanda M. A.;Brenner, Hermann;Casiglia, Edoardo;Chiodini, Paolo;Cooper, Jackie A.;Coresh, Josef;Cushman, Mary;Dankner, Rachel;Davidson, Karina W.;de Jongh, Renate T.;Donfrancesco, Chiara;Engstrom, Gunnar;Freisling, Heinz;de la Camara, Agustin Gomez;Gudnason, Vilmundur;Hankey, Graeme J.;Hansson, PerOlof;Heath, Alicia K.;Hoorn, Ewout J.;Imano, Hironori;Jassal, Simerjot K.;Kaaks, Rudolf;Katzke, Verena;Kauhanen, Jussi;Kiechl, Stefan;Koenig, Wolfgang;Kronmal, Richard A.;Kyro, Cecilie;Lawlor, Deborah A.;Ljungberg, Borje;MacDonald, Conor;Masala, Giovanna;Meisinger, Christa;Melander, Olle;Iribas, Conchi Moreno;Ninomiya, Toshiharu;Nitsch, Dorothea;Nordestgaard, Borge G.;OnlandMoret, Charlotte;Palmieri, Luigi;Petrova, Dafina;Garcia, Jose Ramon Quiros;Rosengren, Annika;Sacerdote, Carlotta;Sakurai, Masaru;Santiuste, Carmen;Schulze, Matthias B.;Sieri, Sabina;Sundstrom, Johan;Tikhonoff, Valerie;Tjonneland, Anne;Tong, Tammy;Tumino, Rosario;Tzoulaki, Ioanna;van der Schouw, Yvonne T.;Verschuren, W. M. Monique;Volzke, Henry;Wallace, Robert B.;Wannamethee, S. Goya;Weiderpass, Elisabete;Willeit, Peter;Woodward, Mark;Yamagishi, Kazumasa;ZamoraRos, Raul;Akwo, Elvis A.;Pyarajan, Saiju;Gagnon, David R.;Tsao, Philip S.;Muralidhar, Sumitra;Edwards, Todd L.;Damrauer, Scott M.;Joseph, Jacob;Pennells, Lisa;Wilson, Peter W. F.;Harrison, Seamus;Gaziano, Thomas A.;Inouye, Michael;Baigent, Colin;Casas, Juan P.;Langenberg, Claudia;Wareham, Nick;Riboli, Elio;Gaziano, J. Michael;Danesh, John;Hung, Adriana M.;Butterworth, Adam S.;Wood, Angela M.;Di Angelantonio, Emanuele
• 通讯作者: Di Angelantonio, Emanuele

Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease.

暴饮暴食和遗传风险是酒精相关肝病的决定因素。

• DOI: 10.17863/cam.102249
• 发表时间: 2023
• 作者: Ding C

Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage.

遗传性升高的低密度脂蛋白与较低的脑出血风险相关。

• DOI: 10.17863/cam.51634
• 发表时间: 2020
• 作者: Falcone G