RESPIRATION DURING DEVELOPMENT

发育过程中的呼吸

• 批准号: 3096657
• 负责人: JAMES METCALFE
• 金额: $ 62.02万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-06-01 至 1986-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3096657
• 关键词: embryo /fetus; growth /development; pregnancy circulation; pulmonary respiration

Each project in this Program deals with one aspect of respiration during the development of the individual organism. Project A is investigating the effects of exercise upon gas transport and fetal growth and development, using pregnant human subjects and Pygmy goats. Project B is concerned with the effects of diminished uterine blood flow upon the growth and development of the fetus, using guinea pigs as experimental models. Project D centers upon the effects of variations in the oxygen concentration of incubator gas upon the growth and development of the avian embryo before and after hatching. The investigators in Project E are measuring fetal cardiac output, its distribution and its control, using a chronically catheterized fetal sheep preparation. Project F is concerned with understanding the control of fetal water balance in chronically catheterized sheep and chronically prepared guinea pigs, and Project J focuses upon the effects of respiratory depressants and stimulants, comparing their effects in pregnant humans and animals with those in non-pregnant individuals of the same species. In addition to these individual projects, the Program has a core support system which includes conferences and guest professorships, a blood-gas laboratory, an animal facility, a computer facility, a radiation facility, and a central office for keeping the accounts, typing the manuscripts and progress reports, and scheduling patients for studies and the use of other core facilities.

该计划中的每个项目都涉及呼吸的一个方面， 个体有机体的发展。 项目A正在调查 运动对气体运输和胎儿生长发育的影响， 人类实验对象和俾格米羊 项目B关注的是 胎儿生长发育时子宫血流减少， 使用豚鼠作为实验模型。 项目D的中心是 生长时培养箱气体的氧浓度的变化， 鸟类胚胎在孵化前后的发育过程。 的调查员 项目E是测量胎儿心输出量，它的分布和控制， 使用长期插管的胎羊准备。 项目F 关注了解胎儿水平衡的控制， 插入导管的绵羊和长期准备的豚鼠，以及项目J的重点 呼吸抑制剂和兴奋剂的影响，比较他们的 在妊娠人和动物中的作用与在非妊娠个体中的作用 同一物种。 除了这些个别项目外，该方案还有一个核心支助系统， 其中包括会议和客座教授，血气实验室， 动物设施、计算机设施、辐射设施和中心办公室 保管帐目、打印文稿和进度报告，以及 安排病人进行研究和使用其他核心设施。