RESPIRATION DURING DEVELOPMENT

发育过程中的呼吸

• 批准号: 3096657
• 负责人: JAMES METCALFE
• 金额: $ 62.02万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-06-01 至 1986-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3096657
• 关键词: embryo /fetus; growth /development; pregnancy circulation; pulmonary respiration

Each project in this Program deals with one aspect of respiration during the development of the individual organism. Project A is investigating the effects of exercise upon gas transport and fetal growth and development, using pregnant human subjects and Pygmy goats. Project B is concerned with the effects of diminished uterine blood flow upon the growth and development of the fetus, using guinea pigs as experimental models. Project D centers upon the effects of variations in the oxygen concentration of incubator gas upon the growth and development of the avian embryo before and after hatching. The investigators in Project E are measuring fetal cardiac output, its distribution and its control, using a chronically catheterized fetal sheep preparation. Project F is concerned with understanding the control of fetal water balance in chronically catheterized sheep and chronically prepared guinea pigs, and Project J focuses upon the effects of respiratory depressants and stimulants, comparing their effects in pregnant humans and animals with those in non-pregnant individuals of the same species. In addition to these individual projects, the Program has a core support system which includes conferences and guest professorships, a blood-gas laboratory, an animal facility, a computer facility, a radiation facility, and a central office for keeping the accounts, typing the manuscripts and progress reports, and scheduling patients for studies and the use of other core facilities.

该计划中的每个项目都涉及呼吸的一个方面 单个生物体的发展。 项目A正在调查效果 使用怀孕时气体运输和胎儿生长和发育进行运动 人类受试者和侏儒山羊。 项目B关注 子宫血流减少了胎儿的生长和发育， 使用豚鼠作为实验模型。 项目D集中在 生长和 孵化前后的禽类胚胎的发展。 调查人员在 项目E正在测量胎儿心脏输出，其分布和控制， 使用长期导管的胎儿绵羊制备。 项目F是 关注理解长期胎儿水平衡的控制 导管绵羊和长期准备的豚鼠，Project J聚焦 对呼吸抑制剂和兴奋剂的影响，将其比较 对怀孕的人和动物的影响 同一物种。 除这些单独的项目外，该计划还具有核心支持系统 其中包括会议和客座教授职位，一个血气实验室，一个 动物设施，计算机设施，辐射设施和中央办公室 保留帐户，键入手稿和进度报告，以及 安排患者进行研究和其他核心设施的使用。