A novel enzymatic means to confirm correct and safe nasogastric tube placement

一种新的酶法来确认正确和安全的鼻胃管放置

• 批准号: MC_PC_15008
• 负责人: George Hanna
• 金额: $ 62.37万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_15008
• 关键词: novel; enzymatic; means; confirm; correct

At least 1 million nasogastric feeding tubes are used by the NHS every year. Tube misplacements can and do have disastrous consequences, including death (National Patient Safety Agency data 2003-10). Existing methods to verify tube placements, including standard pH testing and the gold-standard chest X-rays, have major drawbacks in cost, usability or safety. We have a new enzymatic test to verify correct tube placement, that our pilot study show to be reliable and accurate, while low cost, simple and requiring no extra user training. The new test has great potential to translate into clinical practice. This project will refine the biochemistry and design of the test to provide a new diagnostic product into the NHS supply chain. It will carry out a clinical trial to further validate the technical performance of the test. Data on cost-effectiveness, clinical utility, clinical pathways and mitigation of barriers will be generated to assess the impact of its commercialisation and promote its adoption by the NHS.

NHS每年至少使用100万根鼻饲管。插管错位可能并确实会造成灾难性后果，包括死亡（国家患者安全局数据，2003-10）。现有的验证试管放置的方法，包括标准pH测试和黄金标准胸部X光检查，在成本、可用性或安全性方面存在重大缺陷。我们有一个新的酶测试来验证正确的管放置，我们的试点研究表明，是可靠和准确的，同时成本低，简单，不需要额外的用户培训。这项新的测试有很大的潜力转化为临床实践。该项目将完善测试的生物化学和设计，为NHS供应链提供新的诊断产品。它将进行临床试验，以进一步验证测试的技术性能。将生成有关成本效益，临床效用，临床路径和障碍缓解的数据，以评估其商业化的影响，并促进NHS的采用。

项目成果

Biomarkers of acute appendicitis: systematic review and cost-benefit trade-off analysis.

• DOI: 10.1007/s00464-016-5109-1
• 发表时间: 2017-03
• 期刊: Surgical endoscopy
• 作者: Acharya A;Markar SR;Ni M;Hanna GB
• 通讯作者: Hanna GB

Development and validation of ester impregnated pH strips for locating nasogastric feeding tubes in the stomach-a multicentre prospective diagnostic performance study.

• DOI: 10.1186/s41512-021-00111-9
• 发表时间: 2021-12-14
• 期刊: Diagnostic and prognostic research
• 作者: Ni M;Adam ME;Akbar F;Huddy JR;Borsci S;Buckle P;Rubulotta F;Carr R;Fotheringham I;Wilson C;Tsang M;Harding S;White N;Hanna GB
• 通讯作者: Hanna GB

Use of Tumor Markers in Gastrointestinal Cancers: Surgeon Perceptions and Cost-Benefit Trade-Off Analysis.

• DOI: 10.1245/s10434-016-5717-y
• 发表时间: 2017-05
• 期刊: Annals of surgical oncology
• 影响因子: 3.7
• 作者: Acharya A;Markar SR;Matar M;Ni M;Hanna GB
• 通讯作者: Hanna GB