权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

European & Developing Countries Clinical Trials Partnership - Ebola

欧洲的

基本信息

批准号：
MC_PC_15017
负责人：
金额：
$ 31.86万
依托单位：
European & Developing Countries Clinical Trials Partnership
依托单位国家：
英国
项目类别：
Intramural
财政年份：
2014
资助国家：
英国
起止时间：
2014 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=MC_PC_15017
关键词：
European Developing Countries Clinical Trials

项目摘要

BackgroundThe outbreak of Ebola virus disease (EVD) in West Africa has catalysed a number of research anddevelopment activities that are focused on delivering effective therapeutic, diagnostic and preventiveinterventions. However, the successful testing and implementation of these interventions requires theavailability of functioning health research infrastructures and increased research capacity in theaffected countries, as well as the willingness of affected populations to engage in research anddevelopment activities. The region affected by the current EVD outbreak had very weak research andhealth care delivery systems following years of civil conflict that left health infrastructures badlydamaged or destroyed. Since the outbreak started, existing research and health care services andavailable human resources have been completely overwhelmed by the demand placed upon them. Inview of this, the European & Developing Countries Clinical Trials Partnership (EDCTP) and the SpecialProgramme for Research and Training in Tropical Diseases (WHO-TDR) have decided to launch a Callfor Proposals to cater for long-term solutions and capacity development around operational and otherclinical research during infectious disease outbreaks resulting in health emergencies. The UK MedicalResearch Council (MRC UK) has also committed to participate in this joint initiative.Overview of the Call for ProposalsThe current research activities being conducted in the affected area are focused on the treatment,prevention and containment of EVD. However, there is still a need for approaches that focus onstrengthening human and health system capacity, including developing approaches that address thesocial nature of the emergency situation. This is a niche that will be addressed by this Call forProposals, which will support activities focusing on:? Capacities of health care workers and laboratory personnel in the conduct of clinical trials in anemergency context? Health system and clinical trial site preparedness? Ethics and regulatory issues in the management of research during emergencies? Community and national health authority support and engagement? Development of guidelines and policies to ensure the protection and safety of health care givers inthe handling of infective materials.This Call for Proposals will complement, add value to and sustain the gains that have been achievedduring the current acute response. The work supported will instil long-term preparedness, not only forEVD, but for any future emergencies that may be caused by outbreaks of other emerging infectiousdiseases.

埃博拉病毒病（EVD）在西非的爆发促进了许多研究和开发活动，这些活动侧重于提供有效的治疗、诊断和预防干预措施。然而，这些干预措施的成功测试和实施需要受影响国家具备运作良好的卫生研究基础设施和提高研究能力，以及受影响人口愿意参与研究和发展活动。受当前EVD疫情影响的地区在多年的国内冲突导致卫生基础设施严重受损或被毁后，研究和卫生保健提供系统非常薄弱。自疫情爆发以来，现有的研究和卫生保健服务以及可用的人力资源已经完全被对它们的需求所淹没。有鉴于此，欧洲和发展中国家临床试验伙伴关系（EDCTP）和热带病研究和培训特别计划（WHO-TDR）决定发起一项征集提案，以满足传染病爆发导致卫生紧急情况期间围绕业务和其他临床研究的长期解决方案和能力发展。英国医学研究理事会（MRC UK）也承诺参与这一联合倡议。提案征集概述目前在疫区进行的研究活动集中在埃博拉病毒病的治疗、预防和遏制上。然而，仍然需要采取注重加强人和卫生系统能力的办法，包括制定处理紧急情况社会性质的办法。这是一个将由本提案征集活动解决的特殊领域，它将支持侧重于以下方面的活动：医护人员和实验室人员在紧急情况下进行临床试验的能力？卫生系统和临床试验中心准备情况？紧急情况下研究管理中的道德和监管问题？社区和国家卫生当局的支持和参与？制定指导方针和政策，确保医护人员在处理传染性材料时的保护和安全。本提案征集将补充、增加和维持当前紧急应对期间取得的成果。所支持的工作将注入长期的准备，不仅针对EVD，而且针对未来可能由其他新出现的传染病爆发引起的任何紧急情况。