CHRONIC MITRAL INSUFFICIENCY

慢性二尖瓣关闭不全

• 批准号: 4694609
• 负责人: R MARCH
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4694609
• 关键词: cardiac output; disease /disorder model; heart circulation; heart disorder diagnosis; heart function; heart surgery; heart ventricle; mitral valve; mitral valve insufficiency; model design /development; oxygen consumption; prosthetic heart valve; ultrasound blood flow measurement

This laboratory study tests the hypothesis that left ventricular function following mitral valve replacement may be better preserved by retaining the tethering effect of the mitral valve apparatus in chronic mitral regurgitation. The specific aims are as follows: we will develop a chronic animal model of mitral regurgitation which allows the repeated measurement of left ventricular systolic and diastolic dimensions and mechanisms, regurgitant and forward flow across the valve (directly and via Doppler ultrasound), myocardial oxygen consumption, and hemodynamics. The effect of the acute loss of all the mitral valve attachments versus loss of the anteriod leaflet attachments versus preservation of all structures on left ventricular mechanics, dimensions, and metabolism will be determined. The utilization of a specifically designed left atrial flow transducer allows direct measurement of regurgitant flow thus permitting further validation of color Doppler mapping - a technique being investigated in this laboratory.

本实验室研究验证了左心室功能的假说