CHRONIC MITRAL INSUFFICIENCY

这项实验室研究验证了左心室功能 二尖瓣置换术后， 慢性二尖瓣狭窄时二尖瓣器的栓系效应 返流程度 本研究的具体目标如下：建立慢性动物模型 二尖瓣返流，允许重复测量左心室 心室收缩和舒张的尺寸和机制，抗心律失常药 和向前流过瓣膜（直接和通过多普勒超声）， 心肌耗氧量和血流动力学。 急性的影响 所有二尖瓣附着丧失与前突丧失 瓣叶附着与保留左侧所有结构 将确定心室力学、尺寸和代谢。 的 利用专门设计的左心房流量传感器 直接测量回流，从而允许进一步验证 彩色多普勒映射-一种正在研究的技术， 实验室

This laboratory study tests the hypothesis that left ventricular function following mitral valve replacement may be better preserved by retaining the tethering effect of the mitral valve apparatus in chronic mitral regurgitation. The specific aims are as follows: we will develop a chronic animal model of mitral regurgitation which allows the repeated measurement of left ventricular systolic and diastolic dimensions and mechanisms, regurgitant and forward flow across the valve (directly and via Doppler ultrasound), myocardial oxygen consumption, and hemodynamics. The effect of the acute loss of all the mitral valve attachments versus loss of the anteriod leaflet attachments versus preservation of all structures on left ventricular mechanics, dimensions, and metabolism will be determined. The utilization of a specifically designed left atrial flow transducer allows direct measurement of regurgitant flow thus permitting further validation of color Doppler mapping - a technique being investigated in this laboratory.