CHRONIC MITRAL INSUFFICIENCY

这项实验室研究验证了一种假设，即左心功能 二尖瓣置换术后保留二尖瓣 二尖瓣装置在慢性二尖瓣病变中的拴系作用 反胃。 具体目标如下：建立慢性动物模型 二尖瓣反流，允许重复测量左 心脏收缩和舒张期的尺寸和机制，返流 和穿过瓣膜的前向血流(直接和通过多普勒超声)， 心肌耗氧量和血流动力学。急性呼吸道感染的影响 所有二尖瓣附着物的丢失与前瓣的丢失 小叶附着物与左侧所有结构的保存 将确定心室的力学、尺寸和新陈代谢。这个 利用专门设计的左房血流换能器 直接测量返流流量，从而允许进一步验证 彩色多普勒成像--这是一项正在研究的技术 实验室。

This laboratory study tests the hypothesis that left ventricular function following mitral valve replacement may be better preserved by retaining the tethering effect of the mitral valve apparatus in chronic mitral regurgitation. The specific aims are as follows: we will develop a chronic animal model of mitral regurgitation which allows the repeated measurement of left ventricular systolic and diastolic dimensions and mechanisms, regurgitant and forward flow across the valve (directly and via Doppler ultrasound), myocardial oxygen consumption, and hemodynamics. The effect of the acute loss of all the mitral valve attachments versus loss of the anteriod leaflet attachments versus preservation of all structures on left ventricular mechanics, dimensions, and metabolism will be determined. The utilization of a specifically designed left atrial flow transducer allows direct measurement of regurgitant flow thus permitting further validation of color Doppler mapping - a technique being investigated in this laboratory.