DIHYDROPYRIDINES BLOCK CALCIUM UPTAKE INTO CEREBELLAR GRANULE CELLS

二氢吡啶阻止小脑颗粒细胞吸收钙

• 批准号: 4696422
• 负责人: E CARBONI
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/4696422
• 关键词: antihypertensive agents; brain cell; calcium; calcium channel blockers; drug metabolism; ion transport; membrane permeability; microglia; neuropharmacology; tissue /cell culture

External calcium can enter a cell through the voltage sensitive calcium channel. In non-neuronal cells as well as peripheral nerves, the depolarization induced uptake of calcium through these channels can be antagonized with the class of drugs called dihydropyridines eg. nitrendipine. We have shown that calcium uptake into primary cultures of cerebellar granule cells can be inhibited by nitrendipine and stimulated by BAY K 8663, a dihydropyridine agonist at the voltage sensitive calcium channel. Thus, this research confirms the prescense of a functional dihydropyridine, voltage sensitive channel in cells from the central nervous system.

外部钙离子可以通过电压敏感的钙离子通道进入细胞 频道 在非神经元细胞以及周围神经中， 通过这些通道的去极化诱导的钙摄取可以 拮抗类药物称为二氢吡啶，如。 尼群地平 我们已经证明，原代培养物的钙吸收 尼群地平可抑制小脑颗粒细胞， BAY K 8663，电压敏感性钙离子通道的二氢吡啶激动剂 频道 因此，这项研究证实了一个功能性的存在， 二氢吡啶，电压敏感性通道在细胞从中央 神经系统