A CLINICAL RESEARCH PROGRAM FOR THE PARTIAL EPILEPSIES

部分性癫痫的临床研究计划

• 批准号: 3099220
• 负责人: JEROME NONE ENGEL
• 金额: $ 84.95万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-01-01 至 1989-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3099220
• 关键词: electroencephalography; human subject; partial seizure; psychophysiology; temporal lobe /cortex disorder

In persons with partial epilepsy seeking relief from seizures by surgical treatment arrays of stereotactically implanted intracerebral electrodes are placed in possible seizure foci and monitored by EEG pattern and extracellular action potentials for several weeks. The temporal-spatial relationship of the onset and development of the ictal EEG during simultaneous registration of the behavioral seizure has proven to be the most reliable evidence for the primary focus, obtained in approximately three-fourths of patients. Computer methods are being developed to quantify interictal abnormalities as a similar index. We hope to develop surface EEG correlates equivalent to detection of depth spiking, establishing areas of speech dominance and memory competence. At the cellular level studies are being conducted on the basic mechanisms of epileptogenesis of neurons in the limbic system, the effects of carbamazepine on these neurons, and ultrastructural and Golgi staining of neurons in excised specimens. Neurophysiological experiments correlate hippocampal neuronal responsiveness to tests of memory, spatial cognitive function, movement, behavioral sequencing, visual receptive fields and during sleep stages. Clinical neuropsychological studies examine the relationship of psychological manifestations of temporal lobe epilepsy to epileptiform discharges and clinical-pathological factors.

部分性癫痫患者通过手术缓解癫痫发作 立体定向植入脑内电极的治疗阵列， 放置在可能的癫痫灶中，并通过EEG模式和细胞外 几周的动作电位。 时空关系 发作期EEG的发作和发展，同时记录 行为癫痫已被证明是最可靠的证据， 在大约四分之三的患者中获得。 计算机方法 正在开发将发作间期异常量化为类似指数。 我们 希望开发与深度尖峰检测等效表面EEG相关性， 建立语言优势和记忆能力的区域。 在细胞水平上，正在进行关于以下基本机制的研究： 癫痫发生的神经元在边缘系统，卡马西平的影响， 这些神经元，和超微结构和高尔基体染色的神经元在切除 标本 神经生理学实验关联海马神经元 对记忆、空间认知功能、运动、 行为顺序、视觉感受野和睡眠阶段。 临床神经心理学研究检查了心理因素之间的关系。 颞叶癫痫的癫痫样放电表现， 临床病理因素。