Determinants of immune restoration disease and persistent immune dysfunction in HIV patients responding to ART

全世界许多人现在接受艾滋病毒/艾滋病的抗逆转录病毒治疗。ART增加了CD 4 T细胞的数量，但不能恢复免疫系统的所有功能。此外，一些患者在对ART做出反应时，原有的继发性感染会严重恶化。我们是第一个描述这些免疫恢复疾病的人，并将在这里研究持续性免疫缺陷的潜在机制和原因。

Many people throughout the world now receive antiretroviral treatment (ART) for HIV-AIDS. ART increases numbers of CD4 T-cells, but does not restore all functions the immune system. In addition, some patients experience serious exacerbations of pre-existing secondary infections when they respond to ART. We were the first to describe these Immune Restoration Diseases and will investigate the underlying mechanisms and the causes of persistent immune deficiency here.