Determinants of insulin-like growth factor (IGF) binding and biological actions of IGF binding protein-6

胰岛素样生长因子 (IGF) 结合的决定因素和 IGF 结合蛋白 6 的生物学作用

• 批准号: nhmrc : 299960
• 负责人: Prof Leon Bach
• 金额: $ 26.66万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/determinants-insulin-like-protein-6/101333
• 关键词: Determinants; insulin; like; growth; factor

Proteins are complex structures usually consisting of a number of distinct regions. Each of these regions may serve different roles. Insulin-like growth factors (IGFs) are important proteins involved in regulating the growth and other properties of cells. The actions of IGFs are in turn regulated by a family of binding proteins (IGFBPs). The aim of this project is to determine the range of actions of one of these IGFBPs and which parts of this IGFBP are involved in these actions. This may lead to new treatments for diseases in which cell growth is disturbed e.g. cancer and diabetes.

蛋白质是复杂的结构，通常由许多不同的区域组成。这些区域中的每一个都可能扮演不同的角色。胰岛素样生长因子（IGFs）是调节细胞生长和其他特性的重要蛋白质。igf的作用反过来由一个结合蛋白家族（igfbp）调节。该项目的目的是确定其中一个IGFBP的作用范围，以及该IGFBP的哪些部分参与这些作用。这可能会为细胞生长受到干扰的疾病（如癌症和糖尿病）带来新的治疗方法。