ISCF HDRUK DIH Sprint Exemplar: Developing an integrated data repository and analysis platform to maximise the impact of large-scale cancer cohort studies

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Over the past 20 years, the applicants have researched a very important question by testing various treatment options in managing the most common malignancy in men: prostate cancer. The largest clinical trial of treatment worldwide enrolled over 80,000 participants, comparing surgery, radiotherapy and active monitoring in prostate cancer patients. The results showed that early treatment reduces rates of the disease spreading, but at the cost of over-treating many men with unpleasant side effects. To distinguish men who need treatment from others who could be harmed by interventions, it is critical to undertake long-term research on samples donated by these participants, to understand features that make a cancer ‘aggressive’, requiring urgent treatment. To optimise this research for scientists everywhere, it is crucial to curate these samples and catalogue all their normal clinical information as well as results from the analysis of their samples in a user-friendly collection, which can be used to mine the information and develop new tests and treatments for the future. This project will develop such a unique collection, using latest digital and computer technologies in collaboration with Databiology, with safe provision of ethics, respecting the wishes of the many participants, so that new research can be undertaken.