Interim support for ISARIC4C Clinical Characterisation Protocol (CCP) activation for acute severe hepatitis in children of unknown cause

为不明原因儿童急性重型肝炎激活 ISARIC4C 临床特征协议 (CCP) 提供临时支持

• 批准号: MC_PC_22004
• 负责人: John Kenneth Baillie
• 金额: $ 9.46万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Intramural
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=MC_PC_22004
• 关键词: Interim; support; ISARIC4C; Clinical; Characterisation

A number of young children in the UK, and across the world, are developing severe acute hepatitis. The cause is unknown. We are a group of doctors and scientists who do research in outbreaks in close partnership with public health agencies. Because our study (called ISARIC4C) is already set up across the whole country, we can recruit patients everywhere, collate data and samples and gain consent for research and development. The ISARIC4C approach brings the scalable capacity and cutting-edge capabilities of the academic sector to help the nation respond to public health challenges in time to make a difference to outcome. We have already shown the strongest evidence for the underlying cause of this disease - a combination of common viruses - by reading the DNA sequence of viruses in samples of blood and liver from children with the disease.We have put together a rapid research plan to tackle the key questions identified by UK public health agencies. To do this, the first thing we need to do is recruit patients and their families into research studies to look for the cause of the disease, understand the role of the immune system, find genetic factors that may explain the disease processes, and suggest new treatments.

英国和世界各地的许多幼儿正在发展严重的急性肝炎。原因不明。我们是一群医生和科学家，他们与公共卫生机构密切合作，研究疾病爆发。因为我们的研究（称为ISARIC 4C）已经在全国范围内建立，我们可以在任何地方招募患者，整理数据和样本，并获得研究和开发的同意。ISARIC 4C方法带来了学术部门的可扩展能力和尖端能力，以帮助国家及时应对公共卫生挑战，从而改变结果。通过阅读患病儿童血液和肝脏样本中病毒的DNA序列，我们已经为这种疾病的根本原因--常见病毒的组合--提供了最有力的证据。我们已经制定了一项快速研究计划，以解决英国公共卫生机构确定的关键问题。要做到这一点，我们需要做的第一件事就是招募患者及其家属参加研究，以寻找疾病的原因，了解免疫系统的作用，找到可能解释疾病过程的遗传因素，并提出新的治疗方法。

项目成果

Genomic investigations of unexplained acute hepatitis in children

儿童不明原因急性肝炎的基因组研究

• DOI: 10.5167/uzh-233329
• 发表时间: 2023
• 作者: Morfopoulou, Sofia