ISARIC - Coronavirus Clinical Characterisation Consortium (ISARIC-4C)

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In 2019 new virus emerged(SARS-CoV-2) that causes a disease termed COVID-19. Thismay be mild but can also be severe, leading to viral pneumonia; about one in 100 infectedpeople are expected to die of it. There are many urgent questions that need answering tohelp control the outbreak and treat patients in the UK:• how long are people infectious, and what body fluids are infectious?• what puts people at higher risk of severe illness?• what is the best way to diagnose the disease?• who should we treat early with drugs, and which drugs cause harm?• does the immune system in some patients do more harm than good?• what other infections(such as pneumonia or flu) happen at the same time?The UK needs a coordinated response to answer these questions as quickly as possible.Over the last 8 years we have been preparing for such a major outbreak; our expert teamis ready to immediately deploy and has already started collecting data and samples fromUK cases.The ISARIC-4C study will provide a foundation for other studies, such as clinical trials ofnew treatments, to help better understand the best way to use interventions.We will provide real-time information about the course of COVID-19 while studying andthe underlying biology that explains illness severity with the goal of controlling spread andbetter treating those who contract it.