ISARIC - Coronavirus Clinical Characterisation Consortium (ISARIC-4C)

2019年出现了一种新的病毒(SARS-CoV-2)，它会导致一种名为新冠肺炎的疾病。这可能是轻微的，但也可能是严重的，导致病毒性肺炎；预计每100名感染者中就有一人死于这种疾病。在英国，有许多紧迫的问题需要回答，以帮助控制疫情和治疗患者：·人的传染性有多长，哪些体液具有传染性？·是什么让人们面临更高的严重疾病风险？·诊断疾病的最佳方法是什么？·我们应该及早用药物治疗谁，哪些药物会造成伤害？·一些患者的免疫系统是弊大于利吗？·哪些其他感染(如肺炎或流感)同时发生？英国需要协调一致的应对措施，以尽可能快地回答这些问题。在过去的8年里，我们一直在为如此大的疫情做准备；我们的专家团队已准备好立即部署，并已开始收集英国病例的数据和样本。ISARIC-4C研究将为其他研究(如新疗法的临床试验)提供基础，以帮助更好地了解使用干预的最佳方式。我们将在研究过程中提供有关新冠肺炎病程的实时信息，以及解释疾病严重程度的潜在生物学，以控制传播并更好地治疗感染者。

In 2019 new virus emerged(SARS-CoV-2) that causes a disease termed COVID-19. Thismay be mild but can also be severe, leading to viral pneumonia; about one in 100 infectedpeople are expected to die of it. There are many urgent questions that need answering tohelp control the outbreak and treat patients in the UK:• how long are people infectious, and what body fluids are infectious?• what puts people at higher risk of severe illness?• what is the best way to diagnose the disease?• who should we treat early with drugs, and which drugs cause harm?• does the immune system in some patients do more harm than good?• what other infections(such as pneumonia or flu) happen at the same time?The UK needs a coordinated response to answer these questions as quickly as possible.Over the last 8 years we have been preparing for such a major outbreak; our expert teamis ready to immediately deploy and has already started collecting data and samples fromUK cases.The ISARIC-4C study will provide a foundation for other studies, such as clinical trials ofnew treatments, to help better understand the best way to use interventions.We will provide real-time information about the course of COVID-19 while studying andthe underlying biology that explains illness severity with the goal of controlling spread andbetter treating those who contract it.